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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Hyung Gyun Yang, Ji Hye Han, Eun Hee Choi, Jae Ho Khanal, Tilak Jeong, Myung Ho Jeong, Tae Cheon Jeong, Hye Gwang |
| Description | Country affiliation: South Korea Author Affiliation: Kim HG ( Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea.) |
| Abstract | Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin isolated from the traditional Chinese herb Artemisia annua L., has recently been shown to possess antitumor activity in various cancer cells. However, the effect of anti-inflammatory potentials of DHA in murine macrophage RAW 264.7 cells has not been studied. The present study investigated the effect of COX-2 and molecular mechanisms by DHA in PMA stimulated RAW 264.7 cells. DHA dose-dependently decreased PMA-induced COX-2 expression and PGE2 production, as well as COX-2 promoter-driven luciferase activity. Additionally, DHA decreased luciferase activity of COX-2 regulation-related transcription factors including NF-κB, AP-1, C/EBP and CREB. DHA also remarkably reduced PMA-induced p65, C/EBPß, c-jun and CREB nuclear translocation. Furthermore, DHA evidently inhibited PMA-induced phosphorylation of AKT and the MAP Kinases, such as ERK, JNK and p38. Taken together, our data indicated that DHA effectively attenuates COX-2 production via down-regulation of AKT and MAPK pathway, revealing partial molecular basis for the anti-inflammatory properties of DHA. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 56 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Anti-inflammatory Agents Pharmacology Artemisinins Cyclooxygenase 2 Metabolism Macrophages Drug Effects Phorbol Esters Adverse Effects Plant Extracts Animals Ccaat-enhancer-binding Proteins Cell Line, Tumor Cyclic Amp Response Element-binding Protein Down-regulation Gene Expression Regulation Luciferases Mice Nf-kappa B Phosphorylation Signal Transduction Tetradecanoylphorbol Acetate Transcription Factor Ap-1 P38 Mitogen-activated Protein Kinases Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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