NDLI: Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch].

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Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch].

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Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch].

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Porto, Luiz Carlos Santos da Silva, Juliana Ferraz, Alexandre de Barros Falcão Corrêa, Dione Silva Dos Santos, Marcela Silva Porto, Caroline Dalla Lana Picada, Jaqueline Nascimento
Spatial Coverage	Brazil
Description	Country affiliation: Brazil Author Affiliation: Porto LC ( Universidade da Região da Campanha (URCAMP), São Borja, RS, Brazil.)
Abstract	The infusion of pecan shells has been used to prevent and control hypercholesterolemia, diabetes and toxicological diseases. The aim of the present study was to evaluate toxicity and mutagenic effects of pecan shells aqueous extract (PSAE). Wistar rats were treated with a single dose of 300 or 2000 mg/kg of PSAE in the acute toxicity test. For the subacute test, the animals received 10 or 100 mg/kg of PSAE for 28 days. The mutagenicity was evaluated using Salmonella/microsome assay in TA1535, TA1537, TA98, TA100 and TA102 S. typhimurium strains in the presence and absence of metabolic activation (S9 mix) and micronucleus test in bone marrow. HPLC analyses indicated the presence of tannins, flavonoids, gallic and ellagic acids. Except for triglycerides, all treated groups presented normal hematological and biochemical parameters. Lower levels of triglycerides and weight loss were observed in the 100 mg/kg group. Mutagenic activities were not detected in S. typhimurium strains and by the micronucleus test. Based on these results, PSAE was not able to induce chromosomal or point mutations, under the conditions tested. The 100mg/kg dose showed significant antihyperlipidemic action, with no severe toxic effects.
File Format	HTM / HTML
ISSN	02786915
Volume Number	59
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Anticholesteremic Agents Adverse Effects Antioxidants Carya Chemistry Nuts Plant Extracts Animals Administration & Dosage Metabolism Biotransformation Brazil Dose-response Relationship, Drug Ethnopharmacology Male Medicine, Traditional Micronucleus Tests Microsomes, Liver Enzymology Mutagenicity Tests Random Allocation Rats Rats, Wistar Surface Properties Toxicity Tests, Acute Toxicity Tests, Subacute Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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