NDLI: Identification of pesticide mixtures and connection between combined exposure and diet.

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Evaluation of genotoxicity of nitrile fragrance ingredients using in vitro and in vivo assays.

Inhibitory effects of astaxanthin, ß-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities.

Lucidone protects human skin keratinocytes against free radical-induced oxidative damage and inflammation through the up-regulation of HO-1/Nrf2 antioxidant genes and down-regulation of NF-κB signaling pathway.

Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.

Antioxidant and anti-fatigue effects of anthocyanins of mulberry juice purification (MJP) and mulberry marc purification (MMP) from different varieties mulberry fruit in China.

Dual role of resveratrol in modulation of genotoxicity induced by sodium arsenite via oxidative stress and apoptosis.

Polycyclic aromatic hydrocarbons in commercial squids from different geographical origins: levels and risks for human consumption.

Safety evaluation of Whole Algalin Protein (WAP) from Chlorella protothecoides.

Preliminary characterization and potential hepatoprotective effect of polysaccharides from Cipangopaludina chinensis.

Comparison of anticancer activity between lactoferrin nanoliposome and lactoferrin in Caco-2 cells in vitro.

Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats.

Factors affecting the bioaccessibility of fluoride from seafood products.

Assessment of the respiratory sensitization potential of proteins using an enhanced mouse intranasal test (MINT).

A review on ochratoxin A transcriptomic studies.

Change in kidney damage biomarkers after 13 weeks of exposing rats to the complex of Paecilomyces sinclairii and its host Bombyx mori larvae.

L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes.

Screening of Lactobacillus strains for their ability to bind benzo(a)pyrene and the mechanism of the process.

The synthetic food colouring agent Allura Red AC (E129) is not genotoxic in a flow cytometry-based micronucleus assay in vivo.

Glyphosate induces human breast cancer cells growth via estrogen receptors.

Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial.

Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.

Effect of cadmium-polluted water on plasma levels of tumor necrosis factor- , interleukin-6 and oxidative status biomarkers in rats: protective effect of curcumin.

14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats.

Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions.

Improvement of biochemical parameters in type 1 diabetic rats after the roots aqueous extract of yacon [Smallanthus sonchifolius (Poepp.& Endl.)] treatment.

Antihyperglycemic activity of Caralluma tuberculata in streptozotocin-induced diabetic rats.

Antioxidant properties and neuroprotective effects of isocampneoside II on hydrogen peroxide-induced oxidative injury in PC12 cells.

Proteomic-based identification of multiple pathways underlying n-butylidenephthalide-induced apoptosis in LNCaP human prostate cancer cells.

Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury.

Reproductive toxicity and thyroid effects in Sprague Dawley rats exposed to low doses of ethylenethiourea.

Identification of pesticide mixtures and connection between combined exposure and diet.

O-Methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation.

Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages.

Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo.

Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo.

Neurotoxic effect of linamarin in rats associated with cassava (Manihot esculenta Crantz) consumption.

Can the L5178Y Tk+/- mouse lymphoma assay detect epigenetic silencing?

Ciclohexadespipeptide beauvericin degradation by different strains of Saccharomyces cerevisiae.

A traditional Chinese medicine JiuHuangLian (Rhizoma coptidis steamed with rice wine) reduces oxidative stress injury in type 2 diabetic rats.

In vitro digestion/Caco-2 cell model to estimate cadmium and lead bioaccessibility/bioavailability in two vegetables: the influence of cooking and additives.

Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats.

A sweet piece of dark chocolate in a hot cup of dark coffee: a novel elixir for a long and happy life?

Infant dietary exposure to dioxins and dioxin-like compounds in Greece.

Nutrients and non-nutrients composition and bioactivity of wild and cultivated Coprinus comatus (O.F.Müll.) Pers.

Assessment of the in vitro and in vivo genotoxicity of extracts and indole monoterpene alkaloid from the roots of Galianthe thalictroides (Rubiaceae).

Activation of the PI3K-AKT-mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation.

Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis.

Role of -lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis.

Mussel oligopeptides ameliorate cognition deficit and attenuate brain senescence in D-galactose-induced aging mice.

Transient effects of 2,4-dichlorophenoxyacetic acid (2,4-D) exposure on some metabolic and free radical processes in goldfish white muscle.

Octaphlorethol A isolated from Ishige foliacea inhibits -MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells.

Resveratrol regulates the cell viability promoted by 17ß-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor and insulin growth factor-1 receptor in BG-1 ovarian cancer cells.

Sasa quelpaertensis Nakai extract and its constituent p-coumaric acid inhibit adipogenesis in 3T3-L1 cells through activation of the AMPK pathway.

Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells.

Protective role of sodium selenite on histopathological lesions, decreased T-cell subsets and increased apoptosis of thymus in broilers intoxicated with aflatoxin B1.

Inhibitory effects of -mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation.

Selaginella tamariscina (Beauv.) possesses antimetastatic effects on human osteosarcoma cells by decreasing MMP-2 and MMP-9 secretions via p38 and Akt signaling pathways.

Dietary exposure of the Belgian adult population to non-dioxin-like PCBs.

Laetiporus sulphureus, edible mushroom from Serbia: investigation on volatile compounds, in vitro antimicrobial activity and in situ control of Aspergillus flavus in tomato paste.

In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells.

The hypothalamic-pituitary-gonadal axis is target of cadmium toxicity. An update of recent studies and potential therapeutic approaches.

κ-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice.

Î³-Tocotrienol induced cell cycle arrest and apoptosis via activating the Bax-mediated mitochondrial and AMPK signaling pathways in 3T3-L1 adipocytes.

Scientific evaluation of the subchronic toxicity of Musca domestica larvae extracts in Sprague Dawley rats.

Sub-acute toxicity profile of a modified resveratrol supplement.

Studies on meso-zeaxanthin for potential toxicity and mutagenicity.

Comparisons of metabolic and physiological changes in rats following short term oral dosing with pesticides commonly found in food.

Inhibitory effect of Nymphaea pubescens Willd. flower extract on carrageenan-induced inflammation and CCl4-induced hepatotoxicity in rats.

Indigofera suffruticosa Mill extracts up-regulate the expression of the π class of glutathione S-transferase and NAD(P)H: quinone oxidoreductase 1 in rat Clone 9 liver cells.

Free radical scavenging and anti-oxidative activities of an ethanol-soluble pigment extract prepared from fermented Zijuan Pu-erh tea.

Safety evaluation of a thermolysin enzyme produced from Geobacillus stearothermophilus.

Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch].

Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant.

Immunostimulatory activity of polysaccharides from Cheonggukjang.

Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils.

Effect of the combined probiotics with aflatoxin B1-degrading enzyme on aflatoxin detoxification, broiler production performance and hepatic enzyme gene expression.

Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling.

Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring.

Acute toxicity of some synthetic cyanogens in rats: time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication.

Response to: 'Green propolis and its inhibitory effect on tumor growth in different systemic malignancies'.

Selective inhibition of the cytochrome P450 isoform by hyperoside and its potent inhibition of CYP2D6.

Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize: Letter to the editor.

Green propolis and its inhibitory effect on tumor growth in different systemic malignancies.

Preliminary assessment of potential toxicity of methylated soybean protein and methylated ß-lactoglobulin in male Wistar rats.

Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells.

Styryl-lactone goniothalamin inhibits TNF- -induced NF-κB activation.

Reply to letter to the editor.

Quantitation of tr-cinnamaldehyde, safrole and myristicin in cola-flavoured soft drinks to improve the assessment of their dietary exposure.

Akebia saponin PA induces autophagic and apoptotic cell death in AGS human gastric cancer cells.

Saucerneol F inhibits tumor necrosis factor- and IL-6 production by suppressing Fyn-mediated pathways in FcÎµRI-mediated mast cells.

Citrinin-induced fluidization of the plasma membrane of the fission yeast Schizosaccharomyces pombe.

Optimization of mead production using response surface methodology.

Can garlic oil ameliorate diabetes-induced oxidative stress in a rat liver model? A correlated histological and biochemical study.

Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion.

Formaldehyde inhalation reduces respiratory mechanics in a rat model with allergic lung inflammation by altering the nitric oxide/cyclooxygenase-derived products relationship.

Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme.

Protective effect of extract of Crataegus pinnatifida pollen on DNA damage response to oxidative stress.

Skin tumorigenic potential of benzanthrone: prevention by ascorbic acid.

Octaphlorethol A, a novel phenolic compound isolated from Ishige foliacea, protects against streptozotocin-induced pancreatic ß cell damage by reducing oxidative stress and apoptosis.

Effects of Bacillus subtilis ANSB060 on growth performance, meat quality and aflatoxin residues in broilers fed moldy peanut meal naturally contaminated with aflatoxins.

Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression.

Dermal absorption and hydrolysis of methylparaben in different vehicles through intact and damaged skin: using a pig-ear model in vitro.

Vitamin B2: a promising adjuvant in cisplatin based chemoradiotherapy by cellular redox management.

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Identification of pesticide mixtures and connection between combined exposure and diet.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Béchaux, Camille Zetlaoui, Mélanie Tressou, Jessica Leblanc, Jean-Charles Héraud, Fanny Crépet, Amélie
Spatial Coverage	France
Description	Country affiliation: France Author Affiliation: Béchaux C ( ANSES, Risk Assessment Department, Maisons-Alfort, France. camille.bechaux@anses.fr)
Abstract	The identification of the major associations of pesticides to which the population is exposed is the first step for the risk assessment of mixtures. Moreover, the interpretation of the mixtures through the individuals' diet and the characterization of potentially high-risk populations constitute a useful tool for risk management. This paper proposes a method based on Non-Negative Matrix Factorization which allows the identification of the major mixtures to which the French population is exposed and the connection between this exposure and the diet. Exposure data of the French population are provided by the Second French Total Diet Study. The NMF is implemented on consumption data to extract consumption systems which are combined with the residue levels to link dietary behavior with exposure to mixtures of pesticides. A clustering of the individuals is achieved in order to highlight clusters of individuals with similar exposure to pesticides/consumption habits. The model provides 6 main consumption systems, 6 associated mixtures of pesticides and the description of the population which is most exposed to each mixture. Two different ways to estimate the matrix providing the mixtures of pesticides to which the population is exposed are suggested. Their advantages in different contexts of risk assessment are discussed.
File Format	HTM / HTML
ISSN	02786915
Volume Number	59
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Diet Adverse Effects Feeding Behavior Food Contamination Models, Statistical Pesticide Residues Toxicity Pesticides Adult Beverages Analysis Child Cluster Analysis Diet Surveys Environmental Exposure Environmental Pollutants Female Food France Humans Male Risk Assessment Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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