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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Singh, Jyotsna Kakkar, Poonam |
| Spatial Coverage | India |
| Description | Country affiliation: India Author Affiliation: Singh J ( Herbal Research Section, CSIR-Indian Institute of Toxicology Research, Post Box No. 80, Mahatma Gandhi Marg, Lucknow 226001, UP, India.) |
| Abstract | A decoction of stem bark of Oroxylum indicum Vent. (OI) is taken (2-3 times/day) by the tribal people of Sikkim, India to treat diabetes but scientific validation of its overall potential is lacking. Present study was aimed to assess in vitro antihyperglycemic activity of standardized OI extract using inhibition of -glucosidase, BSA glycation and enhancement of insulin sensitivity. Antidiabetic and antioxidant modulatory effects of OI extract along with the blood biomarkers of toxic response were studied in streptozotocin (STZ) induced diabetic rats. In vitro analysis showed strong antioxidant capacity of OI -and potential to inhibit BSA glycation and -glucosidase activity which was comparable to standard counterparts. Extract also improved insulin sensitivity in mature 3T3-L1 adipocytes. In vivo effects of OI extract (oral 250 mg/kg b.wt.) on STZ induced type II diabetic rats normalized the antioxidant status (p≤0.01). Analysis of blood biomarkers of toxic response indicated its safety. Lowering of total cholesterol and HDL levels (p≤0.05) and restoration of glycated Hb (p≤0.01) were also found in OI treated diabetic rats. HOMA-IR, QUICKI analysis along with area under the curve analysis showed the capacity of OI extract to enhance the insulin sensitivity significantly (p≤0.01) which was confirmed by increased GLUT-4 translocation in skeletal muscles. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 62 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Antioxidants Pharmacology Diabetes Mellitus, Experimental Drug Therapy Glucose Metabolism Hypoglycemic Agents Insulin Resistance Plant Extracts 3t3-l1 Cells Drug Effects Animals Bignoniaceae Chemistry Biological Transport Blood Glucose Chromatography, High Pressure Liquid India Liver Physiology Male Mice Analysis Plants, Medicinal Rats Rats, Wistar Serum Albumin, Bovine Streptozocin Alpha-glucosidases Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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