NDLI: Salidroside stimulates osteoblast differentiation through BMP signaling pathway.

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Salidroside stimulates osteoblast differentiation through BMP signaling pathway.

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Salidroside stimulates osteoblast differentiation through BMP signaling pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Jin-Jing Zhang, Nian-Fei Mao, Gen-Xiang He, Xiao-Bo Zhan, Yue-Chen Deng, Hong-Bin Song, Dan-Qing Li, Dian-Dong Li, Zhuo-Rong Si, Shu-Yi Qiu, Qiang Wang, Zhen
Description	Author Affiliation: Chen JJ ( The Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China.)
Abstract	Salidroside (SAL) is one of main active components of Rhodiola rosea L. and possesses diverse pharmacological effects. However, the direct role of SAL in bone metabolism remains elusive. In this study, effects of SAL on osteoblast differentiation of murine pluripotent mesenchymal cell line C3H10T1/2 and osteoblastic cell line MC3T3-E1 were examined. We first identified SAL as a potential BMP2 activator in a cell-based screening assay. SAL (0.5-10 µM) could slightly promote the proliferation and greatly increase the alkaline phosphatase (ALP) activity in both cells. Furthermore, SAL increased the mRNA expressions of osteoblast marker genes in either C3H10T1/2 or MC3T3-E1 cells after treatment for different time. Moreover, the mineralization of C3H10T1/2 cells assayed by Alizarin red S staining was dose-dependently increased by SAL. Mechanistically, SAL increased the mRNA level of genes involved in the regulation of BMP signaling pathway, including BMP2, BMP6 and BMP7 and enhanced the phosphorylation of Smad1/5/8 and ERK1/2. The osteogenic effect of SAL was abolished by BMP antagonist noggin or by BMP receptor kinase inhibitor dorsomorphin. Further in vivo study demonstrated that SAL reversed bone loss in ovariectomized rats. Collectively, our findings indicate that SAL regulates bone metabolism through BMP signaling pathway.
File Format	HTM / HTML
ISSN	02786915
Volume Number	62
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2013-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Bone Morphogenetic Proteins Metabolism Cell Differentiation Drug Effects Glucosides Pharmacology Osteoblasts Phenols Animals Biological Markers Bone Morphogenetic Protein 2 Genetics Cell Line Gene Expression Regulation Mice Ovariectomy Phosphorylation Pluripotent Stem Cells Pyrazoles Pyrimidines Rats Rats, Sprague-dawley Signal Transduction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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