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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yuan, Guiping Dai, Shujun Yin, Zhongqiong Lu, Hongke Jia, Renyong Xu, Jiao Song, Xu Li, Li Shu, Yang Zhao, Xinghong |
| Description | Country affiliation: China Author Affiliation: Yuan G ( Analytical & Testing Center, Sichuan University, Chengdu 610065, China.); Dai S ( Analytical & Testing Center, Sichuan University, Chengdu 610065, China); Yin Z ( College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China. Electronic address: yinzhongq@163.com.); Lu H ( College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.); Jia R ( College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.); Xu J ( College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.); Song X ( College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.); Li L ( College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.); Shu Y ( College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.); Zhao X ( College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.) |
| Abstract | The exposure to chemical mixtures is a common and important determinant of toxicity and receives concern for their introduction by inhalation and ingestion. However, few in vivo mixture studies have been conducted to understand the health effects of chemical mixtures compared with single chemicals. In this study, the acute and 90day sub-chronic toxicity tests of combined Pb and Cd were conducted. In the acute toxicity test, the LD50 value of Pb(NO3)2 and CdCl2 mixture by the oral route was 2696.54mg/kg by Bliss method. The sub-chronic treatment revealed that the low-dose combination of Pb and Cd exposures can significantly change the physiological and biochemical parameters of the blood of Sprague-Dawley (SD) rats with dose-response relationship and causes microcytic hypochromic anemia and the damages of liver and kidney of the SD rats to various degrees. Histopathological exams showed that the target organs of Pb and Cd were testicle, liver, and kidneys. These observations suggest that Pb and Cd are practically additive-toxic for the SD rats in oral acute toxicity studies. The lowest observed adverse-effect level in rats may be lower than a dose of 29.96mg/(kgbwday) when administered orally for 90 consecutive days. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 65 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Cadmium Toxicity Lead Animals Dose-response Relationship, Drug Female Lethal Dose 50 Male Rats Rats, Sprague-dawley Toxicity Tests, Acute Toxicity Tests, Subchronic Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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