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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ahmad, Aliya Ramasamy, Kalavathy Jaafar, Siti Murnirah Majeed, Abu Bakar Abdul Mani, Vasudevan |
| Description | Country affiliation: Malaysia Author Affiliation: Ahmad A ( Brain Research Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Campus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia.); Ramasamy K ( Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Campus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia.); Jaafar SM ( Brain Research Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Campus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia.); Majeed AB ( Brain Research Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Campus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia.); Mani V ( Brain Research Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Campus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia. Electronic address: vasudevan@puncakalam.uitm.edu.my.) |
| Abstract | The present study was undertaken to compare the neuroprotective effects between total isoflavones from soybean and tempeh against scopolamine-induced cognitive dysfunction. Total isoflavones (10, 20 and 40mg/kg) from soybean (SI) and tempeh (TI) were administered orally to different groups of rats (n=6) for 15days. Piracetam (400mg/kg, p.o.) was used as a standard drug while scopolamine (1mg/kg, i.p.) was used to induce amnesia in the animals. Radial arm and elevated plus mazes served as exteroceptive behavioural models to measure memory. Brain cholinergic activities (acetylcholine and acetylcholinesterase) and neuroinflammatory activities (COX-1, COX-2, IL-1ß and IL10) were also assessed. Treatment with SI and TI significantly reversed the scopolamine effect and improved memory with TI group at 40mg/kg, p.o. exhibiting the best improvement (p<0.001) in rats. The TI (10, 20 and 40mg/kg, p.o.) significantly increased (p<0.001) acetylcholine and reduced acetylcholinesterase levels. Meanwhile, only a high dose (40mg/kg, p.o.) of SI showed significant improvement (p<0.05) in the cholinergic activities. Neuroinflammation study also showed that TI (40mg/kg, p.o.) was able to reduce inflammation better than SI. The TI ameliorates scopolamine-induced memory in rats through the cholinergic neuronal pathway and by prevention of neuroinflammation. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 65 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Amnesia Prevention & Control Encephalitis Isoflavones Isolation & Purification Receptors, Cholinergic Metabolism Scopolamine Hydrobromide Toxicity Soybeans Chemistry Acetylcholine Acetylcholinesterase Chemically Induced Animals Cyclooxygenase Inhibitors Pharmacology Male Maze Learning Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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