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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ravi, K. B. Raghunatha Reddy, K. R. Shankaranarayanan, J. Deshpande, Jayant V. Juturu, Vijaya Soni, Madhu G. |
| Description | Country affiliation: India Author Affiliation: Ravi KB ( BIONEEDS, Devarahosahally, NH-4, Sompura Hobli, Nelamangala Taluk, Bangalore Rural District 562111, Karnataka, India.); Raghunatha Reddy KR ( BIONEEDS, Devarahosahally, NH-4, Sompura Hobli, Nelamangala Taluk, Bangalore Rural District 562111, Karnataka, India.); Shankaranarayanan J ( OmniActive Health Technologies Ltd., A 131, Road No.1, Wagle Industrial Estate, Thane (West) 400607, Maharastra, India.); Deshpande JV ( OmniActive Health Technologies Ltd., A 131, Road No.1, Wagle Industrial Estate, Thane (West) 400607, Maharastra, India.); Juturu V ( OmniActive Health Technologies Inc., Morristown, NJ 07960, USA.); Soni MG ( Soni and Associates Inc., 973, 37th Place, Vero Beach, FL 32960, USA. Electronic address: sonim@bellsouth.net.) |
| Abstract | The available evidence suggests a beneficial effect of zeaxanthin against the progression of age-related macular degeneration (AMD). The objective of the present study was to investigate potential adverse effects of OmniXan™, a RR-zeaxanthin (65%) enriched product obtained from paprika (Capsicum annum fruits) in subchronic toxicity and mutagenicity studies. The oral LD50 of OmniXan(TM) in rats was greater than 2000 mg/kgbody weight (bw)/day. For the subchronic toxicity study, Wistar rats (10/sex/group) were gavaged daily with zeaxanthin concentrate at doses of 0, 4, 40 and 400 mg/kg bw/day for 90-days. No treatment related clinical signs and mortalities observed. Similarly, no treatment related toxicologically significant changes in body weight, feed consumption; ophthalmoscopic examination, neurological examination, hematology, urine analysis and organ weights were observed. Statistically significant changes observed in some clinical chemistry parameters were considered toxicologically and biologically insignificant and nonadverse. Macroscopic and microscopic examinations did not reveal treatment-related abnormalities. The results of mutagenicity testing using Salmonella typhimurium did not reveal any genotoxicity. The no observed-adverse-effect level (NOAEL) for zeaxanthin concentrate (OmniXan(TM)) was determined as 400 mg/kg bw/day, the highest dose tested. The findings of this subchronic toxicity and mutagenicity studies support safety of zeaxanthin concentrate. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 72 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Mutagenicity Tests Toxicity Tests, Acute Toxicity Tests, Chronic Zeaxanthins Toxicity Animals Capsicum Chemistry Dna Damage Drug Effects Dose-response Relationship, Drug Female Fruit Lethal Dose 50 Male No-observed-adverse-effect Level Organ Size Plant Extracts Rats Rats, Wistar Salmonella Typhimurium Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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