NDLI: Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs

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Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs

Content Provider	MDPI
Author	Hussain, Haya Ahmad, Shujaat Shah, Syed Wadood Ali Ullah, Abid Ali, Niaz Almehmadi, Mazen Ahmad, Manzoor Khalil, Atif Ali Khan Jamal, Syed Babar Ahmad, Hanif Halawi, Mustafa
Copyright Year	2022
Description	Alzheimer’s disease is an emerging health disorder associated with cognitive decline and memory loss. In this study, six curcumin analogs (1a–1f) were synthesized and screened for in vitro cholinesterase inhibitory potential. On the basis of promising results, they were further investigated for in vivo analysis using elevated plus maze (EPM), Y-maze, and novel object recognition (NOR) behavioral models. The binding mode of the synthesized compounds with the active sites of cholinesterases, and the involvement of the cholinergic system in brain hippocampus was determined. The synthesized curcumin analog 1d (p < 0.001, n = 6), and 1c (p < 0.01, n = 6) showed promising results by decreasing retention time in EPM, significantly increasing % SAP in Y-maze, while significantly (p < 0.001) enhancing the % discrimination index (DI) and the time exploring the novel objects in NORT mice behavioral models. A molecular docking study using MOE software was used for validation of the inhibition of cholinesterase(s). It has been indicated from the current research work that the synthesized curcumin analogs enhanced memory functions in mice models and could be used as valuable therapeutic molecules against neurodegenerative disorders. To determine their exact mechanism of action, further studies are suggested.
Starting Page	2468
e-ISSN	14203049
DOI	10.3390/molecules27082468
Journal	Molecules
Issue Number	8
Volume Number	27
Language	English
Publisher	MDPI
Publisher Date	2022-04-11
Access Restriction	Open
Subject Keyword	Molecules Curcumin Analogs Alzheimer's Disease Amnesia Acetylcholinesterase Butyrylcholinesterase Docking Scopolamine Epm Y-maze Nort Hippocampus
Content Type	Text
Resource Type	Article

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