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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nakamori, Taizo Fujimori, Akira Kinoshita, Keiji Ban-nai, Tadaaki Kubota, Yoshihisa Yoshida, Satoshi |
| Description | Country affiliation: Japan Author Affiliation: Nakamori T ( Environmental Radiation Effects Research Group, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. taizo@ynu.ac.jp) |
| Abstract | The gene expression of environmental organisms is useful as a biomarker of environmental pollution. One of its advantages is high sensitivity. We identified the cDNA of a novel cadmium-responsive gene in the soil collembolan Folsomia candida. The deduced protein, designated 'metallothionein-like motif containing protein' (MTC), was cysteine-rich and contained a metallothionein-like motif with similarity to metallothionein, but had a much longer sequence than metallothionein and contained repeated sequences of amino acids. Expression of MTC mRNA was sensitively induced by cadmium exposure at 0.3 mg/kg of dry food, a concentration at which toxic effects are not observed, but expression was not affected by gamma-ray exposure (an inducer of oxidative stress). These findings suggest that MTC is involved in cadmium-binding processes rather than in oxidative-stress responses. In conclusion, we suggest that gene expression of MTC may be a candidate biomarker for detecting low levels of cadmium contamination in soil. |
| File Format | HTM / HTML |
| ISSN | 02697491 |
| Issue Number | 5 |
| Volume Number | 158 |
| e-ISSN | 18736424 |
| Journal | Environmental Pollution |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Discipline Science Cadmium Toxicity Environmental Exposure Gene Expression Drug Effects Insect Proteins Genetics Insects Soil Pollutants Animals Biological Markers Analysis Metabolism Environmental Monitoring Rna, Messenger Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Pollution Medicine Toxicology |
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