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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kos, Monika Kahru, Anne Drobne, Damjana Singh, Shashi Kalcíková, Gabriela Kühnel, Dana Rohit, Rekulapelly Gotvajn, Andreja Zgajnar Jemec, Anita |
| Description | Author Affiliation: Kos M ( Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia. Electronic address: monika.kos@bf.uni-lj.si.); Kahru A ( National Institute of Chemical Physics and Biophysics, Laboratory of Environmental Toxicology, Akadeemia tee 23, 12618 Tallinn, Estonia. Electronic address: anne.kahru@kbfi.ee.); Drobne D ( Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia. Electronic address: damjana.drobne@bf.uni-lj.si.); Singh S ( The Centre for Cellular & Molecular Biology, Habsiguda, Hyderabad, Telangana 500007, India. Electronic address: shashis@ccmb.res.in.); Kalcíková G ( Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, 1000 Ljubljana, Slovenia. Electronic address: gabriela.kalcikova@fkkt.uni-lj.si.); Kühnel D ( Helmholtz-Centre for Environmental Research - UFZ, Department of Bioanalytical Ecotoxicology, Permoserstr. 15, 04318 Leipzig, Germany. Electronic address: dana.kuehnel@ufz.de.); Rohit R ( The Centre for Cellular & Molecular Biology, Habsiguda, Hyderabad, Telangana 500007, India. Electronic address: r@ccmb.res.in.); Gotvajn AZ ( Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, 1000 Ljubljana, Slovenia. Electronic address: andreja.zgajnar@fkkt.uni-lj.si.); Jemec A ( Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia. Electronic address: anita.jemec@bf.uni-lj.si.) |
| Abstract | Brine shrimp Artemia sp. has been recognised as an important ecotoxicity and nanotoxicity test model organism for salt-rich aquatic environments, but currently there is still no harmonised testing protocol which would ensure the comparable results for hazard identification. In this paper we aimed to design the harmonised protocol for nanomaterial toxicity testing using Artemia franciscana and present a case study to validate the protocol with silver nanoparticles (AgNPs). We (i) revised the existing nanotoxicity test protocols with Artemia sp. (ii) optimised certain methodological steps based on the experiments with AgNPs and potassium dichromate (K2Cr2O7) as a soluble reference chemical and (iii) tested the optimised protocol in an international inter-laboratory exercise conducted within the EU FP7 NanoValid project. The intra- and inter-laboratory reproducibility of the proposed protocol with a soluble reference chemical K2Cr2O7 was good, which confirms the suitability of this assay for conventional chemicals. However, the variability of AgNPs toxicity results was very high showing again that nanomaterials are inherently challenging for toxicity studies, especially those which toxic effect is linked to shed metal ions. Among the identified sources for this variability were: the hatching conditions, the type of test plate incubation and the illumination regime. The latter induced variations assumingly due to the changes in bioavailable silver species concentrations. Up to our knowledge this is the first inter-laboratory comparison of the Artemia sp. toxicity study involving nanomaterials. Although the inter-laboratory exercise revealed poor repeatability of AgNPs toxicity results, this study provides valuable information regarding the importance of harmonisation of all steps in the test procedure. Also, the presented AgNPs toxicity case study may serve as a platform for further validation steps with other types of NMs. |
| File Format | HTM / HTML |
| ISSN | 02697491 |
| Journal | Environmental Pollution |
| Volume Number | 213 |
| e-ISSN | 18736424 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Pollution Medicine Toxicology |
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