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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yao, Xiu-Qiong Ouyang, Jian-Ming Peng, Hua Zhu, Wen-Yu Chen, He-Qun |
| Description | Country affiliation: China Author Affiliation: Yao XQ ( Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China.); Ouyang JM ( Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China.); Peng H ( Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China.); Zhu WY ( Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China.); Chen HQ ( Department of Urology, Xiang Ya Hospital, Central Southern University, Changsha 410008, China.) |
| Abstract | This paper investigated the inhibitory effect of degraded soybean polysaccharide (DPS) on the growth of calcium oxalate (CaOxa) crystals. The results were compared with that of soybean polysaccharide without degradation (SPS). The data showed that DPS exhibited a much higher efficiency to inhibit CaOxa growth and stabilize calcium oxalate dihydrate (COD) compared with SPS. As DPS concentration increased, the soluble Ca(2+) ions significantly increased, the aggregation degree of calcium oxalate monohydrate (COM) crystals decreased, the shape of COD crystals became round and blunt, and the Zeta potential on CaOxa crystal surface reduced. The above results were all conducive for the inhibition of CaOxa crystallization. In addition, DPS displayed a distinct repairing effect on oxidative injured renal epithelial cells in African green monkey (Vero), with enhanced cell viability and extracellular superoxide dismutase activity after repair. The morphologies of the repaired cells and their regulatory capability on CaOxa growth were between the control and injured cells. The results indicated that the risk of stone formation can be reduced by DPS, and that DPS may be a potential green drug to prevent the formation of CaOxa stones. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Issue Number | 1 |
| Volume Number | 90 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Calcium Oxalate Antagonists & Inhibitors Chemistry Epithelial Cells Drug Effects Kidney Polysaccharides Pharmacology Soybeans Animals Cell Survival Physiology Cercopithecus Aethiops Crystallization Cytology Isolation & Purification Vero Cells Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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