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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Esawy, Mona A. Amer, Hassan Gamal-Eldeen, Amira M. El Enshasy, Hesham A. Helmy, Wafaa A. Abo-Zeid, Mona A. M. Malek, Roslinda Ahmed, Eman F. Awad, Ghada E. A. |
| Description | Country affiliation: Egypt Author Affiliation: Esawy MA ( Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, Giza, Egypt. mona_esawy@hotmail.com) |
| Abstract | Honey isolate Bacillus subtilis M was cultivated in shake flasks and in 16-l bioreactor cultures to investigate cell growth, bio-metabolites production kinetics and bioprocess scalability. The respective maximal levan and levansucrase productions of 59.5 g/l and 74.1 U/ml were achieved in bioreactor cultures under pH controlled condition (pH=7.0) after only 24 h. Crude levan (levE) was isolated, characterized and fractionated into F1, F2, and F3 with different molecular weight (21.8, 13.118, 9.53 kDa). (1)H NMR and (13)C NMR spectroscopy proved that LevE and their fractions were mainly ß-(2, 6)-linked levan-type polysaccharide. The cancer chemo-preventive activity indicated that the levE and its fraction 3 were promising inhibitors of cytochrome P-450 1A activity, inducers of glutathione-S-transferase activity in Murine hepatomaHepa1c1c7cells and possessed highest radical scavenging affinity to both ROO and OH. They inhibited the induced-DNA fragmentation. None of the tested samples triggered apoptosis or necrosis in splenocytes, except F2. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Issue Number | 1 |
| Volume Number | 95 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-06-05 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Antineoplastic Agents Metabolism Bacillus Subtilis Fructans Hexosyltransferases Neoplasms Enzymology Animals Isolation & Purification Pharmacology Antioxidants Apoptosis Drug Effects Bioreactors Cell Line, Tumor Cell Proliferation Cytochrome P-450 Cyp1a1 Antagonists & Inhibitors Dna Fragmentation Enzyme Inhibitors Glutathione Transferase Magnetic Resonance Spectroscopy Mice Micronucleus Tests Spleen Cytology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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