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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shelma, R. Sharma, Chandra P. |
| Description | Country affiliation: India Author Affiliation: Shelma R ( Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695012, India.) |
| Abstract | Curcumin has been demonstrated as a potent anticancer agent but its clinical application has been limited by its poor aqueous solubility and bioavailability. Here we describe encapsulation of curcumin in the lauroyl sulphated chitosan with a view to improve its bioavailability. In vitro antioxidant activity of extract of curcumin loaded matrix was investigated and exhibited dose dependent radical scavenging and reducing activity. Cytotoxicity studies carried out with curcumin loaded carrier on C6 cell line and were found to be toxic. Its in vitro effects on proliferation using the C6 cell lines also studied and observed antiproliferation of C6 cell line. Plasma concentration of curcumin-time profiles from pharmacokinetic studies in rats after oral administration showed a 11.5-fold increased pharmacological availability of curcumin with encapsulated curcumin compared with native curcumin. Overall we demonstrate that the curcumin loaded matrix has shown a superior pharmacological availability in vivo over curcumin. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Issue Number | 1 |
| Volume Number | 95 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-06-05 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Antineoplastic Agents Chemistry Antioxidants Chitosan Analogs & Derivatives Curcumin Drug Carriers Adhesiveness Administration, Oral Animals Administration & Dosage Pharmacokinetics Biological Availability Cell Line Cell Line, Tumor Cell Survival Drug Effects Iron Male Nitric Oxide Metabolism Rats Rats, Sprague-dawley Solubility Water Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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