NDLI: Enhanced dissolution and oral bioavailability of tanshinone IIA base by solid dispersion system with low-molecular-weight chitosan.

Please wait, while we are loading the content...

Retaining cytotoxic activity of anthrapyridone CO1 against multidrug resistant cells is related to the ability to induce concomitantly apoptosis and lysosomal death of leukaemia HL60/VINC and HL60/DOX cells

Prophylactic effects of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in erythrocytes in vivo.

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.

Aegle marmelos Correa leaf extract prevents secondary complications in streptozotocin-induced diabetic rats and demonstration of limonene as a potent antiglycating agent.

Anti-inflammatory effect of hexane fraction from Myagropsis myagroides ethanolic extract in lipopolysaccharide-stimulated BV-2 microglial cells.

Downregulation of ß1 -adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John's wort.

Hepatosteatosis and hepatic insulin resistance are blunted by argirein, an anti-inflammatory agent, through normalizing endoplasmic reticulum stress and apoptosis in diabetic liver.

The positive inotropic effect of the ethyl acetate fraction from Erythrina velutina leaves on the mammalian myocardium: the role of adrenergic receptors

Year: 2013 Volume: 65 Issue: 5

Year: 2013 Volume: 65 Issue: 4

Year: 2013 Volume: 65 Issue: 3

Year: 2013 Volume: 65 Issue: 2

Year: 2013 Volume: 65 Issue: 1

Year: 2012 Volume: 64

Year: 2011 Volume: 63

Year: 2010 Volume: 62

Year: 2009 Volume: 61

Year: 2008 Volume: 60

Year: 2007 Volume: 59

Year: 2006 Volume: 58

Year: 2004 Volume: 56

Year: 1991 Volume: 43

Enhanced dissolution and oral bioavailability of tanshinone IIA base by solid dispersion system with low-molecular-weight chitosan.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Qi-yuan Zhang, Zhen-hai Jin, Xin Jiang, Yan-Rong Jia, Xiao-Bin
Description	Country affiliation: China Author Affiliation: Liu QY ( Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, China.)
Abstract	OBJECTIVES: The aim of this study is to improve the dissolution and oral bioavailability of tanshinone IIA (TAN). METHODS: Solid dispersions of TAN with low-molecular-weight chitosan (LMC) were prepared and the in-vitro dissolution and in-vivo performance were evaluated. KEY FINDINGS: At 1 h, the extent of dissolution of TAN from the LMC-TAN system (weight ratio 9 : 1) increased about 368.2% compared with the pure drug. Increasing the LMC content from 9 : 1 to 12 : 1 in this system did not significantly increase the rate and the extent of dissolution. Differential scanning calorimetry, X-ray diffraction and scanning electron microscopy demonstrated the formation of amorphous tanshinone IIA and the absence of crystallinity in the solid dispersion. Fourier transform infrared spectroscopy revealed that there was no interaction between drug and carrier. In-vivo test showed that LMC-TAN solid dispersion system presented significantly larger AUC0-t , which was 0.67 times that of physical mixtures and 1.17 times that of TAN. Additionally, the solid dispersion generated obviously higher Cmax and shortened Tmax compared with TAN and physical mixtures. CONCLUSIONS: In conclusion, the LMC -based solid dispersions could achieve complete dissolution, accelerated absorption rate and superior oral bioavailability.
File Format	HTM / HTML
ISSN	00223573
Issue Number	6
Volume Number	65
e-ISSN	20427158
Journal	Journal of Pharmacy and Pharmacology
Language	English
Publisher	Wiley
Publisher Date	2013-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Chitosan Chemistry Pharmacokinetics Diterpenes, Abietane Administration, Oral Animals Area Under Curve Biological Availability Administration & Dosage Drug Carriers Male Molecular Weight Rats Rats, Sprague-dawley Solubility Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone I and tanshinone IIA extracted from Salvia miltiorrhiza.

Improvement in oral bioavailability and dissolution of tanshinone IIA by preparation of solid dispersions with porous silica.

Improved pH-independent dissolution and oral absorption of valsartan via the preparation of solid dispersion.

Development of a rebamipide solid dispersion system with improved dissolution and oral bioavailability.

Solid dispersion formulations of megestrol acetate with copovidone for enhanced dissolution and oral bioavailability.

Preparation and physicochemical characterizations of tanshinone IIA solid dispersion.

Development of an itraconazole-loaded gelatin microcapsule with enhanced oral bioavailability: physicochemical characterization and in-vivo evaluation.

Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution, and Bioavailability in Rats

Enhanced solubility and bioavailability of flurbiprofen by cycloamylose.

Enhanced dissolution and oral bioavailability of tanshinone IIA base by solid dispersion system with low-molecular-weight chitosan.

Similar Documents

Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone I and tanshinone IIA extracted from Salvia miltiorrhiza.

Improvement in oral bioavailability and dissolution of tanshinone IIA by preparation of solid dispersions with porous silica.

Improved pH-independent dissolution and oral absorption of valsartan via the preparation of solid dispersion.

Development of a rebamipide solid dispersion system with improved dissolution and oral bioavailability.

Solid dispersion formulations of megestrol acetate with copovidone for enhanced dissolution and oral bioavailability.

Preparation and physicochemical characterizations of tanshinone IIA solid dispersion.

Development of an itraconazole-loaded gelatin microcapsule with enhanced oral bioavailability: physicochemical characterization and in-vivo evaluation.

Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution, and Bioavailability in Rats

Enhanced solubility and bioavailability of flurbiprofen by cycloamylose.

Enhanced dissolution and oral bioavailability of tanshinone IIA base by solid dispersion system with low-molecular-weight chitosan.