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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gomes, A. P. Mano, J. F. Queiroz, J. A. Gouveia, I. C. |
| Description | Country affiliation: Portugal Author Affiliation: Gomes AP ( FibEnTech - Fiber Materials and Environmental Technologies - Research Unit, Faculty of Engineering, University of Beira Interior, 6201-001 Covilhã, Portugal.); Mano JF ( 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, Portugal); Queiroz JA ( ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.); Gouveia IC ( FibEnTech - Fiber Materials and Environmental Technologies - Research Unit, Faculty of Engineering, University of Beira Interior, 6201-001 Covilhã, Portugal. Electronic address: igouveia@ubi.pt.) |
| Abstract | A large group of low molecular weight natural compounds that exhibit antimicrobial activity has been isolated from animals and plants during the past two decades. Among them, peptides are the most widespread resulting in a new generation of antimicrobial agents with higher specific activity. In the present study we have developed a new strategy to obtain antimicrobial wound-dressings based on the incorporation of antimicrobial peptides into polyelectrolyte multilayer films built by the alternate deposition of polycation (chitosan) and polyanion (alginic acid sodium salt) over cotton gauzes. Energy dispersive X ray microanalysis technique was used to determine if antimicrobial peptides penetrated within the films. FTIR analysis was performed to assess the chemical linkages, and antimicrobial assays were performed with two strains: Staphylococcus aureus (Gram-positive bacterium) and Klebsiella pneumonia (Gram-negative bacterium). Results showed that all antimicrobial peptides used in this work have provided a higher antimicrobial effect (in the range of 4 log-6 log reduction) for both microorganisms, in comparison with the controls, and are non-cytotoxic to normal human dermal fibroblasts at the concentrations tested. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 127 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Anti-bacterial Agents Pharmacology Antimicrobial Cationic Peptides Cotton Fiber Klebsiella Pneumoniae Drug Effects Staphylococcus Aureus Alginates Chemistry Cell Survival Chitosan Electrolytes Fibroblasts Cytology Glucuronic Acid Hexuronic Acids Humans Growth & Development Microbial Sensitivity Tests Skin Structure-activity Relationship Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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