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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mishra, Bibaswan Sahoo, Jagannath Dixit, Prasanna Kumar |
| Description | Author Affiliation: Mishra B ( Gayatri College of Pharmacy, Sambalpur, Odisha 768200, India. Electronic address: drbibaswanmishra@gmail.com.); Sahoo J ( Shri Ram Murti Smarak College of Engg. and Technology (Pharmacy), Bareilly, U.P. 243202, India. Electronic address: drjagannathsahoo@gmail.com.); Dixit PK ( Department of Zoology, Berhampur University, Ganjam, Odisha 760007, India. Electronic address: drdixit2001@gmail.com.) |
| Abstract | In present study precipitation-ultrasonication was used to obtain nanosuspensions of poorly water-soluble drug, naproxen (NPX). We investigated the effects of HPMC concentration (X1) and time of ultrasonication (X2) on imperative attributes like mean particle size (Y1), % drug content (Y2), and time required to 90% drug release (Y3) via 3(2) factorial design. The morphology of nanosuspensions was found almost spherical by SEM observation. DSC and XRD studies suggested slight crystalline change in drug. FT-IR revealed lack of significant interactions between NPX and HPMC. Nanosuspensions of mean particle size 530.55 nm was achieved. Dissolution rate obtained from all nanosuspensions were markedly higher than pure NPX. Response surface methodology and optimized polynomial equations were used to select optimal formulation i.e. 1.36%W/V of X1 and 13.9 min of X2 to get desired response Y1; 727.97 nm, Y2; 95.59% and Y3; 8.67 min that were in reasonable agreement with observed value. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Journal | Carbohydrate Polymers |
| Volume Number | 127 |
| e-ISSN | 18791344 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Hypromellose Derivatives Chemistry Nanoparticles Naproxen Solubility Sonication Suspensions Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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