| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Nwaru, Bright I. Hayes, Helen Gambling, Lorraine Craig, Leone C. A. Allan, Keith Prabhu, Nanda Turner, Steven W. McNeill, Geraldine Erkkola, Maijaliisa Seaton, Anthony McArdle, Harry J. Devereux, Graham |
| Description |
Country affiliation: United kingdom Author Affiliation: Nwaru BI ( Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh,Edinburgh,UK.); Hayes H ( Rowett Institute of Nutrition and Health, University of Aberdeen,AberdeenAB25 2ZG,UK.); Gambling L ( Rowett Institute of Nutrition and Health, University of Aberdeen,AberdeenAB25 2ZG,UK.); Craig LC ( Public Health Nutrition Group, University of Aberdeen,AberdeenAB25 2ZG,UK.); Allan K ( Department of Child Health,Royal Aberdeen Children's Hospital, University of Aberdeen,AberdeenAB25 2ZG,UK.); Prabhu N ( Department of Child Health,Royal Aberdeen Children's Hospital, University of Aberdeen,AberdeenAB25 2ZG,UK.); Turner SW ( Department of Child Health,Royal Aberdeen Children's Hospital, University of Aberdeen,AberdeenAB25 2ZG,UK.); McNeill G ( Public Health Nutrition Group, University of Aberdeen,AberdeenAB25 2ZG,UK.); Erkkola M ( Division of Nutrition, Department of Food and Environmental Sciences, University of Helsinki,Helsinki,Finland.); Seaton A ( Department of Environmental and Occupational Medicine,University of Aberdeen,AberdeenAB25 2ZG,UK.); McArdle HJ ( Rowett Institute of Nutrition and Health, University of Aberdeen,AberdeenAB25 2ZG,UK.); Devereux G ( Department of Child Health,Royal Aberdeen Children's Hospital, University of Aberdeen,AberdeenAB25 2ZG,UK.) |
| Abstract |
Maternal nutritional status during pregnancy has been reported to be associated with childhood asthma and atopic disease. The Avon Longitudinal Study of Parents and Children has reported associations between reduced umbilical cord Fe status and childhood wheeze and eczema; however, follow-up was short and lung function was not measured. In the present study, the associations between maternal Fe status during pregnancy and childhood outcomes in the first 10 years of life were investigated in a subgroup of 157 mother-child pairs from a birth cohort with complete maternal, fetal ultrasound, blood and child follow-up data. Maternal Fe intake was assessed using FFQ at 32 weeks of gestation and Hb concentrations and serum Fe status (ferritin, soluble transferrin receptor and TfR-F (transferrin receptor:ferritin) index) were measured at 11 weeks of gestation and at delivery. Maternal Fe intake, Hb concentrations and serum Fe status were found to be not associated with fetal or birth measurements. Unit increases in first-trimester maternal serum TfR concentrations (OR 1.44, 95% CI 1.05, 1.99) and TfR-F index (OR 1.42, 95% CI 1.10, 1.82) (i.e. decreasing Fe status) were found to be associated with an increased risk of wheeze, while unit increases in serum ferritin concentrations (i.e., increasing Fe status) were found to be associated with increases in standardised mean peak expiratory flow (PEF) (ß 0.25, 95% CI 0.09, 0.42) and forced expiratory volume in the first second (FEV1) (ß 0.20, 95% CI 0.08, 0.32) up to 10 years of age. Increasing maternal serum TfR-F index at delivery was found to be associated with an increased risk of atopic sensitisation (OR 1.35, 95% CI 1.02, 1.79). The results of the present study suggest that reduced maternal Fe status during pregnancy is adversely associated with childhood wheeze, lung function and atopic sensitisation, justifying further studies on maternal Fe status and childhood asthma and atopic disease. |
| File Format |
HTM / HTML |
| ISSN |
00071145 |
| Issue Number |
12 |
| Volume Number |
112 |
| e-ISSN |
14752662 |
| Journal |
British Journal of Nutrition |
| Language |
English |
| Publisher |
Cambridge University Press (on behalf of The Nutrition Society) |
| Publisher Date |
2014-12-28 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Nutritional Discipline Sciences Anemia, Iron-deficiency Complications Asthma Etiology Ferritins Blood Hypersensitivity, Immediate Iron Prenatal Exposure Delayed Effects Receptors, Transferrin Adult Physiopathology Child Child, Preschool Cohort Studies Female Forced Expiratory Volume Hemoglobins Metabolism Humans Infant Infant, Newborn Administration & Dosage Deficiency Iron, Dietary Lung Male Nutritional Status Odds Ratio Peak Expiratory Flow Rate Pregnancy Pregnancy Complications Pregnancy Trimester, First Respiratory Sounds Questionnaires Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Nutrition and Dietetics Medicine |
