NDLI: Increased Expression of Cullin 3 in Nasopharyngeal Carcinoma and Knockdown Inhibits Proliferation and Invasion

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Increased Expression of Cullin 3 in Nasopharyngeal Carcinoma and Knockdown Inhibits Proliferation and Invasion

Content Provider	Tech Science Press
Author	Tan, Guolin Ma, Yanhong Li, Wei Zeng, Ruifang
Abstract	This study aimed to investigate the clinical significance of cullin 3 expression in nasopharyngeal carcinoma (NPC), as well as to explore the regulatory mechanism of cullin 3 underlying the growth and metastasis of NPC cells. Our findings showed that the expression levels of cullin 3 were significantly increased in both NPC tissues and cell lines. A strong positive correlation was found between cullin 3 expression and the Ki-67-based proliferation index in NPC tissues. Moreover, cullin 3 overexpression was correlated with local relapse and distant metastasis in NPC patients. In vitro experiments showed that knockdown of cullin 3 caused a significant reduction in the proliferation of NPC cells, probably by inducing cell cycle arrest. In addition, downregulation of cullin 3 inhibited colony formation and the migratory and invasive capacities of NPC cells. The expression levels of PCNA and epithelial-to-mesenchymal transition (EMT)-related proteins were also meditated by cullin 3 in NPC cells. Based on these findings, we demonstrated that cullin 3 plays a promoting role in the malignant progression of NPC and suggest that the cullin 3-based ubiquitin proteasome pathway may be used as a promising therapeutic target for NPC.
Related Links	https://www.techscience.com/or/v26n1/56623
Starting Page	111
Ending Page	122
ISSN	09650407
DOI	10.3727/096504017X14924753593574
Issue Number	1
Journal	Oncology Research (OR)
Volume Number	26
e-ISSN	15553906
Language	English
Access Restriction	Open
Subject Keyword	Tumor progression Cullin 3 Nasopharyngeal carcinoma (NPC) Prognosis Survival
Content Type	Text
Resource Type	Article
Subject	Cancer Research

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