NDLI: Long Noncoding RNA UCA1 Targets miR-122 to Promote Proliferation, Migration, and Invasion of Glioma Cells

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Long Noncoding RNA UCA1 Targets miR-122 to Promote Proliferation, Migration, and Invasion of Glioma Cells

Content Provider	Tech Science Press
Author	Meng, Qiang Mi, Wei-yang Jin, Jun-gong Zhang, Shi-tao Hao-wu Zhang, Shi-rong Sun, Yang
Abstract	Glioma is the most common and lethal malignant intracranial tumor. Long noncoding RNAs (lncRNAs) have been identified as pivotal regulators in the tumorigenesis of glioma. However, the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in glioma genesis is still unknown. The purpose of this study was to investigate the underlying function of UCA1 on glioma genesis. The results demonstrated that UCA1 was upregulated in glioma tissue and indicated a poor prognosis. UCA1 knockdown induced by si-UCA1 significantly suppressed the proliferative, migrative, and invasive activities of glioma cell lines (U87 and U251). Bioinformatics analysis and luciferase reporter assay verified the complementary binding within UCA1 and miR-122 at the 3'-UTR. Functional experiments revealed that UCA1 acted as an miR-122 “sponge” to modulate glioma cell proliferation, migration, and invasion via downregulation of miR-122. Overall, the present study demonstrated that lncRNA UCA1 acts as an endogenous sponge of miR-122 to promote glioma cell proliferation, migration, and invasion, which provides a novel insight and therapeutic target in the tumorigenesis of glioma.
Related Links	https://www.techscience.com/or/v26n1/56622
Starting Page	103
Ending Page	110
ISSN	09650407
DOI	10.3727/096504017X14934860122864
Issue Number	1
Journal	Oncology Research (OR)
Volume Number	26
e-ISSN	15553906
Language	English
Access Restriction	Open
Subject Keyword	Long noncoding RNAs (lncRNAs) Migration miR-122 Glioma Invasion Urothelial carcinoma-associated 1 (UCA1)
Content Type	Text
Resource Type	Article
Subject	Cancer Research

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