LAPTM4B promotes the progression of nasopharyngeal cancer.

Content Provider	Europe PMC
Author	Su, Qun Luo, Hongtao Zhang, Ming Gao, Liying Zhao, Fengju
Copyright Year	2021
Abstract	Lysosomal protein transmembrane 4 beta (LAPTM4B) is a protein that contains four transmembrane domains. The impact of LAPTM4B on the malignancy of nasopharyngeal carcinoma (NPC) remains unclear. In the present study, we aimed to investigate the role of LAPTM4B in NPC. NPC tissue samples were used to evaluate the expression of LAPTM4B and its relationship with patient prognosis. Furthermore, we inhibited the expression of LAPTM4B in NPC cell lines and examined the effects of LAPTM4B on NPC cell proliferation, migration, and invasion. We found that LAPTM4B protein was mainly localized in the cytoplasm and intracellular membranes of NPC cells. LAPTM4B protein was upregulated in NPC tissues and cell lines. High LAPTM4B expression was closely related to pathological subtypes and disease stages in NPC patients. NPC patients with high LAPTM4B expression had a worse prognosis. LAPTM4B knockdown inhibited the proliferation, migration, and invasion ability of NPC cells. LAPTM4B plays a cancer-promoting role in the progression of NPC and may be a potential target for NPC therapy.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8112566&blobtype=pdf
ISSN	15128601
Journal	Bosnian Journal of Basic Medical Sciences [Bosn J Basic Med Sci]
Volume Number	21
DOI	10.17305/bjbms.2020.4738
PubMed Central reference number	PMC8112566
Issue Number	3
PubMed reference number	32651973
e-ISSN	18404812
Language	English
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Publisher Date	2021-06-01
Publisher Place	Bosnia
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution 4.0 International License Copyright: © The Author(s) (2021)
Subject Keyword	NPC LAPTM4B prognosis proliferation migration invasion
Content Type	Text
Resource Type	Article
Subject	Medicine