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| Content Provider | Taylor & Francis Online |
|---|---|
| Author | Tanamas, Stephanie Peeters, Anna Wolf, Rory Wong, Evelyn Abdullah, Asnawi Amin, Fauzi Ali Stoelwinder, Johannes Hanum, Farida |
| Abstract | BackgroundWe have recently demonstrated that an obese-years construct is a better predictor of the risk of diabetes than the severity of body weight alone. However, these risk estimates were derived from a population cohort study initiated in 1948 that might not apply to the current population.ObjectiveTo validate an obese-years construct in estimating the risk of type-2 diabetes in a more contemporary cohort study.DesignA total of 5,132 participants of the Framingham Offspring Study, initiated in 1972, were followed up for 45 years. Body mass index (BMI) above 29 kg/m2 was multiplied by the number of years lived with obesity at that BMI to define the number of obese-years. Time-dependent Cox regression was used to explore the association.ResultsThe risk of type-2 diabetes increased significantly with increase in obese-years. Adjusted hazard ratios increased by 6% (95% CI: 5–7%) per additional 10 points of obese-years. This ratio was observed to be similar in both men and women, but was 4% higher in current smokers than in never/ex-smokers. The Akaike Information Criterion confirmed that the Cox regression model with the obese-years construct was a stronger predictor of the risk of diabetes than a model including either BMI or the duration of obesity alone.ConclusionsIn a contemporary cohort population, it was confirmed that the obese-years construct is strongly associated with an increased risk of type-2 diabetes. This suggests that both severity and the duration of obesity should be considered in future estimations of the burden of disease associated with obesity. |
| File Format | PDF HTM / HTML |
| ISSN | 16549716 16549880 |
| DOI | 10.3402/gha.v9.30421 |
| Journal | Global Health Action |
| Volume Number | 9 |
| Issue Number | 1 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2016-06-30 |
| Access Restriction | Open |
| Subject Keyword | BMI Obesity Offspring Framingham Obese-years Type-2 diabetes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Public Health, Environmental and Occupational Health Health Policy |
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