NDLI: P152 Prediction of Death or Heart Failure-related Hospitalizations by Cardio-ankle Vascular Index (CAVI) and CAVI0

Content Provider	Springer Nature : BioMed Central
Author	Spronck, Bart Lee, Jonathan Oldland, Garrett Obeid, Mary Jo Paravathaneni, Mahati Gadela, Naga Vaishnavi Ans, Armghan Singh, Gurpreet Bhuva, Rushik Akers, Scott Chirinos, Julio
Abstract	Background Arterial stiffness as measured by carotid-femoral pulse wave velocity (PWV) has been shown to predict cardiovascular events [1]. However, PWV is blood pressure (BP) dependent [2,3] leading to the development of cardio-ankle vascular index (CAVI) as a more blood pressure-independent index [4] that also shows predictive ability in Asian populations [5]. Recently, CAVI was further refined into CAVI0 [6], removing residual acute blood pressure dependence [7]. The present study aims to assess risk prediction by CAVI and CAVI0 in a US population. Methods We enrolled 156 subjects (94.8% male; 47.7% African-American) with and without heart failure. Subjects underwent arterial stiffness assessments (VaSera 1500 N, Fukuda Denshi Co., Tokyo, Japan). Left (L-CAVI) and right (R-CAVI) measurements were obtained from the device, CAVI0’s were converted from CAVI’s taking into account CAVI’s scale coefficients [8,9]. We prospectively followed participants for a mean of 2.56 years for the composite endpoint of death or heart failure related hospital admission. Results L-CAVI and R-CAVI did not differ significantly (9.80 ± 2.11 vs 9.66 ± 1.92, p = 0.146); neither did L-CAVI0 and R-CAVI0 (16.51 ± 5.85 vs 16.15 ± 5.34, p = 0.178). In unadjusted Cox regression, R-CAVI, L-CAVI, and R-CAVI0 but not L-CAVI0 predicted outcome (Table 1). After adjustment for age, sex, race, and systolic BP, only right-sided CAVIs and CAVI0s were predictive. Discussion We observed possible body-side differences in prediction using CAVI and CAVI0. A previous study cross-sectionally reported more pronounced body side differences in heart-to-ankle PWV related to cardiovascular disease [10]; we are unaware of published prospective studies observing this. In conclusion, both R-CAVI and R-CAVI0 predicted heart-failure related end-points. n Standardized HR [95% CI] p Unadjusted L-CAVI 155 1.33 [1.01–1.76] 0.042 R-CAVI 156 1.52 [1.10–2.11] 0.011 L-CAVI0 155 1.28 [0.97–1.68] 0.078 R-CAVI0 156 1.39 [1.04–1.87] 0.027 Adjusted for age, sex, race, and systolic BP L-CAVI 154 1.35 [0.99–1.83] 0.06 R-CAVI 155 1.55 [1.08–2.21] 0.016 L-CAVI0 154 1.30 [0.95–1.77] 0.10 R-CAVI0 155 1.39 [1.0´–1.9´] 0.044 s-HR, standardized hazard ratio; CI, confidence interval. Table Cox regression results
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.2991/artres.k-191224.172.pdf
Ending Page	S190
Page Count	2
Starting Page	S189
File Format	HTM / HTML
ISSN	18764401
DOI	10.2991/artres.k-191224.172
Journal	Artery Research
Issue Number	1
Volume Number	25
Language	English
Publisher	BioMed Central
Publisher Date	2020-02-17
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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