NDLI: P107 Endothelial Dysfunction Associated with Arterial Stiffness in Postmenopausal Women with Obesity

Content Provider	Springer Nature : BioMed Central
Author	Lizette Ramírez Soltero, Patricia Benavides, Leonel García Pantoja, Marycruz Barocio Illescas Vidrio, Brandon Giovanni Müller, David Cardona Cardona Muñoz, Ernesto Germán Totsuka Sutto, Sylvia Elena
Abstract	Background Endothelial dysfunction (ED) represents an initial step of “vascular failure” [1]; several factors affect the functionality of the endothelium. Obesity [2] and estrogen deficiency [3] are independently associated with this. The early detection of ED is essential to intervene and prevent its progression. One of the most promising methods to assess vascular endothelial function is the measurement of endothelium- dependent flow-mediated vasodilation (FMD) [1]. Similarly, pulse wave velocity (PWV) is considered as a predictive value for the stratification of vascular risk [4], however, progression between endothelial events and arterial stiffness continues to be examined. Objective To evaluate the association between endothelial dysfunction and arterial stiffness in postmenopausal women with obesity. Methods Descriptive study of 19 postmenopausal women with grade I and II obesity, without associated comorbidities. Participants were classified into one of two groups: with ED (FMD < 6%) or non-ED (FMD > 6%). The hemodynamic metabolic, hormonal and arterial stiffness parameters were evaluated. Results The group with ED (n = 10) compared to the non-ED group (n = 9) presented age 57.30 ± 4.80 vs 52.40 ± 5.70 years (p = NS); BMI 34.75 ± 2.06 vs 33.06 ± 2.51 kg/m2 (p = NS). Statically significant findings include: FSH 35.43 ± 11.04 vs 55.19 ± 19.27 mUI/ml (p = 0.018); PWV 9.18 ± 1.84 vs 7.52 ± 1.26 m/s (p = 0.041); central SBP 135 ± 15.90 vs 120 ± 18.2 mmHg (p = 0.041). We also measure estradiol, QIMT, SBP, DBP, PP, AIx, LDL-C, HDL-C and triglycerides, no significant differences were observed. Conclusion We can conclude that in the group with endothelial dysfunction the PWV and the cSBP are higher with a significant difference.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.2991/artres.k.191224.133.pdf
Ending Page	S147
Page Count	1
Starting Page	S147
File Format	HTM / HTML
ISSN	18764401
DOI	10.2991/artres.k.191224.133
Journal	Artery Research
Issue Number	1
Volume Number	25
Language	English
Publisher	BioMed Central
Publisher Date	2020-02-17
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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