NDLI: Plasma Cathepsin L Level is Positively Associated with Arterial Stiffness in Geriatric Patients

Content Provider	Springer Nature : BioMed Central
Author	Xu, Jun Pan, Feng-Feng Xu, Chan-Chan Zhong, Yuan Hu, Ting-Jun Fu, Guo-Xiang
Abstract	Background Cathepsin L (Cat L) is involved in the regulation of vascular aging processes. The aim of this study was to evaluate the relationship between plasma Cat L level and arterial stiffness marker through brachial-ankle pulse wave velocity (baPWV) in geriatric patients. Methods Cross-sectional study with 502 people were selected from a population of 2250 people aged over 65 years old, from three different basic health zones of Shanghai. Blood samples were collected, and the baPWV was measured with the SphygmoCor system. The geriatric patients with baPWV values >20 m/s were defined as the high arterial stiffness group. Results In total, 248 (49.4%) of the 502 geriatric patients in this study were in the high arterial stiffness group. The high arterial stiffness group were older (p = 0.006) and had higher prevalence of hypertension (p = 0.020), coronary heart disease (CHD) (p = 0.037), higher systolic blood pressure (SBP) (p = 0.018), pulse pressure (p = 0.017), plasma Cat L (p = 0.002) and logarithmically transformed C-reactive protein (p = 0.023) levels than those in the low arterial stiffness group. Multivariable forward stepwise regression analysis showed that Cat L (β = 0.418, p = 0.011) and hypertension (β = 0.217, p = 0.029) were associated with baPWV values in geriatric patients. Moreover, an increased plasma Cat L level (odds ratio (OR): 1.048; 95% confidence interval (CI): 1.043–1.169; p = 0.018) was an independent factor for arterial stiffness among the geriatric patients. Conclusion In this study, plasma Cat L level was positively correlated with arterial stiffness in geriatric patients.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.2991/artres.k.191125.001.pdf
Ending Page	69
Page Count	5
Starting Page	65
File Format	HTM / HTML
ISSN	18764401
DOI	10.2991/artres.k.191125.001
Journal	Artery Research
Issue Number	1
Volume Number	25
Language	English
Publisher	BioMed Central
Publisher Date	2019-12-04
Access Restriction	Open
Subject Keyword	Medicine Public Health Arterial stiffness cathepsin L geriatric patients Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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