| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Han, Mengzhen Liao, Zhibin Liu, Furong Chen, Xiaoping Zhang, Bixiang |
| Abstract | Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some promising therapy targets. However, further mechanisms remain to be researched to improve the therapeutic strategy and diagnosis of HCC. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which plays critical roles in networks of different cellular processes, and TGF-β signaling has been found to participate in tumor initiation and development of HCC in recent years. Moreover, among the molecules and signaling pathways, researchers paid more attention to lncRNAs (long non-coding RNAs), but the connection between lncRNAs and TGF-βremain poorly understood. In this review, we conclude the malignant procedure which lncRNAs and TGF-β involved in, and summarize the mechanisms of lncRNAs and TGF-βin HCC initiation and development. Furthermore, the interaction between lncRNA and TGF-β are paid more attention, and the potential therapy targets are mentioned. |
| Related Links | https://biomarkerres.biomedcentral.com/counter/pdf/10.1186/s40364-020-00252-x.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20507771 |
| DOI | 10.1186/s40364-020-00252-x |
| Journal | Biomarker Research |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-12-01 |
| Access Restriction | Open |
| Subject Keyword | Biomedicine Cancer Research Long noncoding RNA TGF-β Hepatocellular carcinoma Therapy target |
| Content Type | Text |
| Resource Type | Review |
| Subject | Biochemistry (medical) Molecular Medicine Clinical Biochemistry |
| Journal Impact Factor | 9.5/2023 |
| 5-Year Journal Impact Factor | 9.4/2023 |
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