| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Wu, Yongfeng Xu, Jinming Xu, Jiawei Wang, Yiqing Wang, Luming Lv, Wang Hu, Jian |
| Abstract | High tumor mutation burden (TMB), which is associated with increased tumor immunogenicity, has been identified to predict improved response to immune checkpoint inhibitors (ICIs) therapy in non-small cell lung cancer (NSCLC). As host immunity is also significant to eliminate cancer cells, however, its clinical impact on cancer immunotherapy is still largely unknown. Here we explored the influence of age, which is an important characteristic to evaluate immune response of patients, on TMB-based predictive system for ICIs therapy in NSCLC. Our results showed that high TMB was capable of predicting better durable clinical benefit (DCB) in agelow group, while it was insignificant in agehigh group. Besides, the predictive power of TMB for progression-free survival (PFS) and overall survival (OS) was better in agelow group than in agehigh group. Our study illustrated that the predictive value of TMB for ICIs therapy was better in young patients than in elderly patients in NSCLC. |
| Related Links | https://biomarkerres.biomedcentral.com/counter/pdf/10.1186/s40364-020-00188-2.pdf |
| Ending Page | 5 |
| Page Count | 5 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20507771 |
| DOI | 10.1186/s40364-020-00188-2 |
| Journal | Biomarker Research |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-04-09 |
| Access Restriction | Open |
| Subject Keyword | Biomedicine Cancer Research Tumor mutation burden TMB Age Immune checkpoint inhibitor ICI NSCLC Immunosenescence |
| Content Type | Text |
| Subject | Biochemistry (medical) Molecular Medicine Clinical Biochemistry |
| Journal Impact Factor | 9.5/2023 |
| 5-Year Journal Impact Factor | 9.4/2023 |
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