| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Gamez-Nava, Jorge Ivan Diaz-Rizo, Valeria Perez-Guerrero, Edsaul Emilio Muñoz-Valle, Jose Francisco Saldaña-Cruz, Ana Miriam Fajardo-Robledo, Nicte Selene Jacobo-Cuevas, Heriberto Nava-Valdivia, Cesar Arturo Alcaraz-Lopez, Miriam Fabiola Trujillo, Xochitl Huerta, Miguel Cardona-Muñoz, Ernesto German Gonzalez-Lopez, Laura |
| Abstract | Background To date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial. Objective To assess the utility of serum MIF, leptin, adiponectin and resistin levels as markers of proteinuria and renal dysfunction in lupus nephritis. Methods Cross-sectional study including 196 systemic lupus erythematosus (SLE) patients and 52 healthy controls (HCs). Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Renal SLE involvement was investigated by renal-SLEDAI. MIF, adiponectin, leptin and resistin levels were quantified by ELISA. We assessed the correlations of quantitative variables by Spearman correlation (rs). Multivariable linear regression adjusted the variables associated with the severity of proteinuria. Results SLE patients had higher MIF (p = 0.02) and adiponectin (p < 0.001) than HCs. Patients with renal SLE involvement (n = 43) had higher adiponectin (19.0 vs 13.3 μg/mL, p = 0.002) and resistin (10.7 vs 8.9 ng/mL, p = 0.01) than patients with non-renal SLE (n = 153). Proteinuria correlated with high adiponectin (rs = 0.19, p < 0.009) and resistin (rs = 0.26, p < 0.001). MIF (rs = 0.27, p = 0.04). Resistin correlated with increased creatinine (rs = 0.18, p = 0.02). High renal-SLEDAI correlated with adiponectin (rs = 0.21, p = 0.004). Multiple linear regression showed that elevated adiponectin (p = 0.02), younger age (p = 0.04) and low MIF (p = 0.02) were associated with the severity of proteinuria. Low MIF and high adiponectin levels interacted to explain the association with the severity of proteinuria (R2 = 0.41). Conclusions High adiponectin combined with low MIF concentrations int+eract to explain the severity of proteinuria in renal SLE. These findings highlight the relevance of adiponectin, resistin and MIF as markers of LN. |
| Related Links | https://biomarkerres.biomedcentral.com/counter/pdf/10.1186/s40364-020-00236-x.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20507771 |
| DOI | 10.1186/s40364-020-00236-x |
| Journal | Biomarker Research |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-10-28 |
| Access Restriction | Open |
| Subject Keyword | Biomedicine Cancer Research Lupus nephritis Lupus Erythematosus systemic MIF Adiponectin Adipokines Biomarkers |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Molecular Medicine Clinical Biochemistry |
| Journal Impact Factor | 9.5/2023 |
| 5-Year Journal Impact Factor | 9.4/2023 |
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