| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Haikal, Caroline Chen, Qian-Qian Li, Jia-Yi |
| Abstract | Parkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research. |
| Related Links | https://translationalneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s40035-019-0175-7.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20479158 |
| DOI | 10.1186/s40035-019-0175-7 |
| Journal | Translational Neurodegeneration |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-12-24 |
| Access Restriction | Open |
| Subject Keyword | Neurosciences Neurology Parkinson’s disease Intestinal microbiota Inflammation Gut Protein aggregation |
| Content Type | Text |
| Resource Type | Review |
| Subject | Cellular and Molecular Neuroscience Neurology (clinical) Cognitive Neuroscience |
| Journal Impact Factor | 10.8/2023 |
| 5-Year Journal Impact Factor | 11.6/2023 |
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