| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Tian, Chen Liu, Genliang Gao, Liyan Soltys, David Pan, Catherine Stewart, Tessandra Shi, Min Xie, Zhiying Liu, Na Feng, Tao Zhang, Jing |
| Abstract | Background Erythrocytes are a major source of peripheral α-synuclein (α-Syn). The goal of the current investigation is to evaluate erythrocytic total, oligomeric/aggregated, and phosphorylated α-Syn species as biomarkers of Parkinson’s disease (PD). PD and healthy control blood samples were collected along with extensive clinical history to determine whether total, phosphorylated, or aggregated α-Syn derived from erythrocytes (the major source of blood α-Syn) are more promising and consistent biomarkers for PD than are free α-Syn species in serum or plasma. Methods Using newly developed electrochemiluminescence assays, concentrations of erythrocytic total, aggregated and phosphorylated at Ser129 (pS129) α-Syn, separated into membrane and cytosolic components, were measured in 225 PD patients and 133 healthy controls and analyzed with extensive clinical measures. Results The total and aggregated α-Syn levels were significantly higher in the membrane fraction of PD patients compared to healthy controls, but without alterations in the cytosolic component. The pS129 level was remarkably higher in PD subjects than in controls in the cytosolic fraction, and to a lesser extent, higher in the membrane fraction. Combining age, erythrocytic membrane aggregated α-Syn, and cytosolic pS129 levels, a model generated by using logistic regression analysis was able to discriminate patients with PD from neurologically normal controls, with a sensitivity and a specificity of 72 and 68%, respectively. Conclusions These results suggest that total, aggregated and phosphorylated α-Syn levels are altered in PD erythrocytes and peripheral erythrocytic α-Syn is a potential PD biomarker that needs further validation. |
| Related Links | https://translationalneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s40035-019-0155-y.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20479158 |
| DOI | 10.1186/s40035-019-0155-y |
| Journal | Translational Neurodegeneration |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-05-15 |
| Access Restriction | Open |
| Subject Keyword | Neurosciences Neurology Parkinson’s disease α-Synuclein Erythrocyte Electrochemiluminescence |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cellular and Molecular Neuroscience Neurology (clinical) Cognitive Neuroscience |
| Journal Impact Factor | 10.8/2023 |
| 5-Year Journal Impact Factor | 11.6/2023 |
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