NDLI: Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model

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Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model

Content Provider	Springer Nature : BioMed Central
Author	Müller, Hans-Peter Brenner, David Roselli, Francesco Wiesner, Diana Abaei, Alireza Gorges, Martin Danzer, Karin M. Ludolph, Albert C. Tsao, William Wong, Philip C. Rasche, Volker Weishaupt, Jochen H. Kassubek, Jan
Abstract	Background In vivo diffusion tensor imaging (DTI) of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis (ALS). Methods Ten mice with TDP-43G298S overexpression under control of the Thy1.2 promoter and 10 wild type (wt) underwent longitudinal DTI scans at 11.7 T, including one baseline and one follow-up scan with an interval of about 5 months. Whole brain-based spatial statistics (WBSS) of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43G298S mice compared to wt at the cohort level. Results were supplemented by tractwise fractional anisotropy statistics (TFAS) and histological evaluation of motor cortex for signs of neuronal loss. Results Alterations at the cohort level in TDP-43G298S mice were observed cross-sectionally and longitudinally in motor areas M1/M2 and in transcallosal fibers but not in the corticospinal tract. Neuronal loss in layer V of motor cortex was detected in TDP-43G298S at the later (but not at the earlier) timepoint compared to wt. Conclusion DTI mapping of TDP-43G298S mice demonstrated progression in motor areas M1/M2. WBSS and TFAS are useful techniques to localize TDP-43G298S associated alterations over time in this ALS mouse model, as a biological marker.
Related Links	https://translationalneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s40035-019-0163-y.pdf
Ending Page	13
Page Count	13
Starting Page	1
File Format	HTM / HTML
ISSN	20479158
DOI	10.1186/s40035-019-0163-y
Journal	Translational Neurodegeneration
Issue Number	1
Volume Number	8
Language	English
Publisher	BioMed Central
Publisher Date	2019-08-30
Access Restriction	Open
Subject Keyword	Neurosciences Neurology Mutant TDP-43 Diffusion tensor imaging Amyotrophic lateral sclerosis Fiber tracking Mouse brain
Content Type	Text
Resource Type	Article
Subject	Cellular and Molecular Neuroscience Neurology (clinical) Cognitive Neuroscience
Journal Impact Factor	10.8/2023
5-Year Journal Impact Factor	11.6/2023

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