NDLI: Altered fractionation short-course radiotherapy for stage II-III rectal cancer: a retrospective study

Content Provider	Springer Nature : BioMed Central
Author	Geinitz, Hans Nieder, Carsten Kocik, Lukas Track, Christine Feichtinger, Johann Weingartner, Theresa Spiegl, Kurt Füreder-Kitzmüller, Barbara Kaufmann, Johanna Seewald, Dietmar H. Függer, Reinhold Shamiyeh, Andreas Petzer, Andreas L. Kiesl, David Hammer, Josef
Abstract	Purpose To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer. Patients and Methods: This was a retrospective single institution study with median follow-up of 101 months (8.4 years). Patients who were alive at the time of analysis in 2018 were contacted to obtain functional outcome data (phone interview). Radiotherapy consisted of 25 Gy in 10 fractions of 2.5 Gy administered twice daily. Median time interval to surgery was 5 days. Results Local relapse was observed in 12 patients (4.4%) after a median of 28 months. Overall survival after 5 and 10 years was 73 and 55.5%, respectively (corresponding disease-free survival 65.5 and 51%). Of all patients without permanent stoma, 79% reported no low anterior resection syndrome (LARS; 0–20 points), 9% reported LARS with 21–29 points and 12% serious LARS (30–42 points). Conclusion The present radiotherapy regimen was feasible and resulted in low rates of local relapse. Most patients reported good functional outcomes.
Related Links	https://ro-journal.biomedcentral.com/counter/pdf/10.1186/s13014-020-01566-8.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13014-020-01566-8
Journal	Radiation Oncology
Issue Number	1
Volume Number	15
Language	English
Publisher	BioMed Central
Publisher Date	2020-05-14
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Radiotherapy Imaging Radiology Stage II-III rectal cancer Neoadjuvant altered fractionation short-course radiotherapy Low anterior resection syndrome (LARS)
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Oncology
Journal Impact Factor	3.3/2023
5-Year Journal Impact Factor	3.6/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Concomitant boost IMRT-based neoadjuvant chemoradiotherapy for clinical stage II/III rectal adenocarcinoma: results of a phase II study

Management of Low Anterior Resection Syndrome (LARS) Following Resection for Rectal Cancer.

Current status of neoadjuvant therapy for locally advanced rectal cancer in Wuhan Union Hospital Cancer Center

A phase II trial of neoadjuvant IMRT-based chemoradiotherapy followed by one cycle of capecitabine for stage II/III rectal adenocarcinoma

EP-1424: Palliative short-course radiotherapy in rectal cancer: a phase II study

Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma

MRI response rate after short-course radiotherapy on rectal cancer in the elderly comorbid patient: results from a retrospective cohort study

Sphincter preservation in distal CT2N0 rectal cancer after preoperative chemoradiotherapy

Is radiotherapy necessary for upper rectal cancer underwent curative resection? A retrospective study of 363 patients

Altered fractionation short-course radiotherapy for stage II-III rectal cancer: a retrospective study

Similar Documents

Concomitant boost IMRT-based neoadjuvant chemoradiotherapy for clinical stage II/III rectal adenocarcinoma: results of a phase II study

Management of Low Anterior Resection Syndrome (LARS) Following Resection for Rectal Cancer.

Current status of neoadjuvant therapy for locally advanced rectal cancer in Wuhan Union Hospital Cancer Center

A phase II trial of neoadjuvant IMRT-based chemoradiotherapy followed by one cycle of capecitabine for stage II/III rectal adenocarcinoma

EP-1424: Palliative short-course radiotherapy in rectal cancer: a phase II study

Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma

MRI response rate after short-course radiotherapy on rectal cancer in the elderly comorbid patient: results from a retrospective cohort study

Sphincter preservation in distal CT2N0 rectal cancer after preoperative chemoradiotherapy

Is radiotherapy necessary for upper rectal cancer underwent curative resection? A retrospective study of 363 patients

Altered fractionation short-course radiotherapy for stage II-III rectal cancer: a retrospective study