| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Yamada, Laís Akemi Mariano, Isabela Ramos Sabino, Vanessa Lara Rissi Rabassi, Renan Soares Bataglini, Camila Azevedo, Silvia Carla Santana Ferreira Branquinho, Nayra Thais Delatorre Kurauti, Mirian Ayumi Garcia, Rosângela Fernandes Pedrosa, Maria Montserrat Diaz |
| Abstract | Background Caloric restriction since birth changes glucose metabolism by the liver in overnight-fasted rats to a fed-like pattern, in which glucose output is large but gluconeogenesis is negligible. It was investigated whether these changes could be a residual effect of the nutritional condition during lactation and what could be the mechanism of such change. Methods Newborn Wistar rat pups were arranged in litters of 6 or 12 (G6 and G12). After weaning, the male pups were divided in: G6L and G12 L, fed freely until the age of 90 days (freely-fed groups); G6R and G12R, given 50% of the GL ingestion (food-restricted groups) until 90 days of age; G6RL and G12RL, given 50% of the GL ingestion until 60 days of age and fed freely until 90 days of age (refed groups). The experimental protocols were carried out at the age of 90 days after overnight fasting. Pairs of groups were compared through t test; other statistical comparisons were made with one-way ANOVA with Tukey post hoc text. Results Caloric restriction was effective in decreasing body and fat weights, total cholesterol and LDL. These effects were totally or partially reversed after 30 days of refeeding (groups GRL). During liver perfusion, the high glucose output of the GRs was further enhanced by adrenaline (1 μM), but not by lactate infusion. In contrast, in groups G6L, G12 L, G6RL and G12RL glycogenolysis (basal and adrenaline-stimulated glucose output) was low and gluconeogenesis from lactate was significant. A twofold increase in liver content of PKA in group G6R suggests that liver sensitivity to glucagon and adrenaline was higher because of caloric restriction, resulting in enhanced glucose output. Conclusions As glucose output was not affected by litter size, liver glucose metabolism in the adult rat, in contrast to other metabolic processes, is not a programmed effect of the nutritional condition during lactation. In addition, the increased expression of PKA points to a higher sensitivity of the animals under caloric restriction to glycogenolytic hormones, a relevant condition for glucose homeostasis during fasting. |
| Related Links | https://nutritionandmetabolism.biomedcentral.com/counter/pdf/10.1186/s12986-019-0413-0.pdf |
| Ending Page | 10 |
| Page Count | 10 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17437075 |
| DOI | 10.1186/s12986-019-0413-0 |
| Journal | Nutrition & Metabolism |
| Issue Number | 1 |
| Volume Number | 16 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-12-12 |
| Access Restriction | Open |
| Subject Keyword | Clinical Nutrition Metabolic Diseases Caloric restriction Litter size Liver metabolism Glycogenolysis Gluconeogenesis Metabolic programming |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Endocrinology, Diabetes and Metabolism Nutrition and Dietetics |
| Journal Impact Factor | 3.9/2023 |
| 5-Year Journal Impact Factor | 4.3/2023 |
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