NDLI: Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499

Content Provider	Springer Nature : BioMed Central
Author	Wu, Luting Ran, Li Lang, Hedong Zhou, Min Yu, Li Yi, Long Zhu, Jundong Liu, Lei Mi, Mantian
Abstract	Background Reprogramming of fast-to-slow myofiber switch can improve endurance capacity and alleviate fatigue. Accumulating evidence suggests that a muscle-specific microRNA, miR-499 plays a crucial role in myofiber type transition. In this study, we assessed the effects of natural flavonoid myricetin on exercise endurance and muscle fiber constitution, and further investigated the underlying mechanism of myricetin in vivo and in vitro. Methods A total of 66 six-week-old male Sprague Dawley rats were divided into non-exercise or exercise groups with/without orally administered myricetin (50 or 150 mg/kg) for 2 or 4 weeks. Time-to-exhaustion, blood biochemical parameters, muscle fiber type proportion, the expression of muscle type decision related genes were measured. Mimic/ inhibitor of miR-499 were transfected into cultured L6 myotubes, the expressions of muscle type decision related genes and mitochondrial respiration capacity were investigated. Results Myricetin treatment significantly improved the time-to-exhaustion in trained rats. The enhancement of endurance capacity was associated with an increase of the proportion of slow-twitch myofiber in both soleus and gastrocnemius muscles. Importantly, myricetin treatment amplified the expression of miR-499 and suppressed the expression of Sox6, the down-stream target gene of miR-499, both in vivo and in vitro. Furthermore, inhibition of miR-499 overturned the effects of myricetin on down-regulating Sox6. Conclusions Myricetin promoted the reprogramming of fast-to-slow muscle fiber type switch and reinforced the exercise endurance capacity. The precise mechanisms responsible for the effects of myricetin are not resolved but likely involve regulating miR-499/Sox6 axis.
Related Links	https://nutritionandmetabolism.biomedcentral.com/counter/pdf/10.1186/s12986-019-0353-8.pdf
Ending Page	13
Page Count	13
Starting Page	1
File Format	HTM / HTML
ISSN	17437075
DOI	10.1186/s12986-019-0353-8
Journal	Nutrition & Metabolism
Issue Number	1
Volume Number	16
Language	English
Publisher	BioMed Central
Publisher Date	2019-05-02
Access Restriction	Open
Subject Keyword	Clinical Nutrition Metabolic Diseases Myricetin Endurance Muscle fiber type Myosin heavy chain miR-499
Content Type	Text
Resource Type	Article
Subject	Medicine Endocrinology, Diabetes and Metabolism Nutrition and Dietetics
Journal Impact Factor	3.9/2023
5-Year Journal Impact Factor	4.3/2023

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Correction to: Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499

The carnitine status does not affect the contractile and metabolic phenotype of skeletal muscle in pigs

Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene

Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise

Carnitine supplementation to obese Zucker rats prevents obesity-induced type I to type II muscle fiber transition and favors an oxidative phenotype of skeletal muscle

Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle

Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells

Piperine enhances carbohydrate/fat metabolism in skeletal muscle during acute exercise in mice

Erratum to: Carnitine supplementation to obese Zucker rats prevents obesity-induced type I to type II muscle fiber transition and favors an oxidative phenotype of skeletal muscle

Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499

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Correction to: Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499

The carnitine status does not affect the contractile and metabolic phenotype of skeletal muscle in pigs

Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene

Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise

Carnitine supplementation to obese Zucker rats prevents obesity-induced type I to type II muscle fiber transition and favors an oxidative phenotype of skeletal muscle

Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle

Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells

Piperine enhances carbohydrate/fat metabolism in skeletal muscle during acute exercise in mice

Erratum to: Carnitine supplementation to obese Zucker rats prevents obesity-induced type I to type II muscle fiber transition and favors an oxidative phenotype of skeletal muscle

Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499