| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Saul, Dominik Weber, Marie Zimmermann, Marc Hendrik Kosinsky, Robyn Laura Hoffmann, Daniel Bernd Menger, Björn Taudien, Stefan Lehmann, Wolfgang Komrakova, Marina Sehmisch, Stephan |
| Abstract | Background Osteoporosis is one of the world’s major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a lipoxygenase inhibitor, may rescue bone loss. Studies evaluating the effect of baicalein in vivo are rare. Methods We administered baicalein to sixty-one three-month-old female Sprague-Dawley rats. They were divided into five groups, four of which were ovariectomized (OVX) and one non-ovariectomized (NON-OVX). Eight weeks after ovariectomy, bilateral tibial osteotomy with plate osteosynthesis was performed and bone formation quantified. Baicalein was administered subcutaneously using three doses (C1: 1 mg/kg BW; C2: 10 mg/kg BW; and C3: 100 mg/kg BW) eight weeks after ovariectomy for four weeks. Finally, femora and tibiae were collected. Biomechanical tests, micro-CT, ashing, histological and gene expression analyses were performed. Results Biomechanical properties were unchanged in tibiae and reduced in femora. In tibiae, C1 treatment enhanced callus density and cortical width and decreased callus area. In the C3 group, callus formation was reduced during the first 3 weeks after osteotomy, correlating to a higher mRNA expression of Osteocalcin, Tartrate-resistant acid phosphatase and Rankl. In femora, baicalein treatments did not alter bone parameters. Conclusions Baicalein enhanced callus density and cortical width but impaired early callus formation in tibiae. In femora, it diminished the biomechanical properties and calcium-to-phosphate ratio. Thus, it is not advisable to apply baicalein to treat early bone fractures. To determine the exact effects on bone healing, further studies in which baicalein treatments are started at different stages of healing are needed. |
| Related Links | https://nutritionandmetabolism.biomedcentral.com/counter/pdf/10.1186/s12986-018-0327-2.pdf |
| Ending Page | 15 |
| Page Count | 15 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17437075 |
| DOI | 10.1186/s12986-018-0327-2 |
| Journal | Nutrition & Metabolism |
| Issue Number | 1 |
| Volume Number | 16 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-01-11 |
| Access Restriction | Open |
| Subject Keyword | Clinical Nutrition Metabolic Diseases Baicalein Lipoxygenase inhibitor Fracture healing Osteoporosis Biomechanics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Endocrinology, Diabetes and Metabolism Nutrition and Dietetics |
| Journal Impact Factor | 3.9/2023 |
| 5-Year Journal Impact Factor | 4.3/2023 |
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