NDLI: Circulating PAMM, a novel antioxidant and anti-inflammatory protein, is elevated in acute SCI

Content Provider	Springer Nature : BioMed Central
Author	Morse, Leslie R. Nguyen, Nguyen Xu, Yan Jha, Prakash Battaglino, Ricardo A.
Abstract	Background Peroxiredoxin activated in M-CSF stimulated monocytes (PAMM) is a novel protein produced by adipocytes with putative redox regulatory and anti-inflammatory properties. Because acute spinal cord injury (SCI) is associated with oxidative stress and neuroinflammation and because PAMM can be detected in systemic circulation, we hypothesized that acute neuro-trauma might induce changes in circulating PAMM expression. Specifically, we hypothesized that PAMM levels might vary based on the presence or absence of acute, traumatic SCI. We therefore investigated circulating PAMM levels in adults with and without acute traumatic SCI. Methods We studied 105 men and women (54 with SCI and 51 without SCI). Participants with SCI were admitted for acute rehabilitation within 1 month after injury. Serum samples were obtained during hospitalization and stored at − 80 °C until batch analysis. Total PAMM was quantified by ELISA assay (MyBiosource, Cat. No: MBS9327247) with a detection limit of 0.25 ng/ml. Separate multivariate models including age, BMI, and injury severity were assessed to determine significant clinical predictors of change in PAMM levels. Results When adjusting for BMI, age, and gender, mean change in PAMM levels were greatest in participants with motor complete SCI compared to able-bodied (1.65 ng/ml versus 0.94 ng/ml, p = 0.003). This model explained 26% of the variation in change in circulating PAMM levels. Conclusions Our results suggest that PAMM may be a novel biomarker of neurological injury or of native anti-inflammatory responses to neurological injury. More work is needed to establish the role of PAMM and other adipocyte-derived factors in the acute response to neurotrauma.
Related Links	https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-020-02304-0.pdf
Ending Page	5
Page Count	5
Starting Page	1
File Format	HTM / HTML
ISSN	14795876
DOI	10.1186/s12967-020-02304-0
Journal	Journal of Translational Medicine
Issue Number	1
Volume Number	18
Language	English
Publisher	BioMed Central
Publisher Date	2020-03-24
Access Restriction	Open
Subject Keyword	Biomedicine Medicine Public Health PAMM Biomarker Inflammation Reactive oxygen species Spinal cord injury Rehabilitation medicine Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	6.1/2023
5-Year Journal Impact Factor	6.3/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species

Inflammogenesis of Secondary Spinal Cord Injury

Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits

Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species

Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model

Ibuprofen use is associated with reduced C-reactive protein and interleukin-6 levels in chronic spinal cord injury.

Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury

Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury

A comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker genes

Circulating PAMM, a novel antioxidant and anti-inflammatory protein, is elevated in acute SCI

Similar Documents

Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species

Inflammogenesis of Secondary Spinal Cord Injury

Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits

Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species

Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model

Ibuprofen use is associated with reduced C-reactive protein and interleukin-6 levels in chronic spinal cord injury.

Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury

Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury

A comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker genes

Circulating PAMM, a novel antioxidant and anti-inflammatory protein, is elevated in acute SCI