NDLI: 3D in vitro hydrogel models to study the human lung extracellular matrix and fibroblast function

Content Provider	Springer Nature : BioMed Central
Author	Phogat, Sakshi Thiam, Fama Al Yazeedi, Safiya Abokor, Filsan Ahmed Osei, Emmanuel Twumasi
Abstract	The pulmonary extracellular matrix (ECM) is a macromolecular structure that provides mechanical support, stability and elastic recoil for different pulmonary cells including the lung fibroblasts. The ECM plays an important role in lung development, remodeling, repair, and the maintenance of tissue homeostasis. Biomechanical and biochemical signals produced by the ECM regulate the phenotype and function of various cells including fibroblasts in the lungs. Fibroblasts are important lung structural cells responsible for the production and repair of different ECM proteins (e.g., collagen and fibronectin). During lung injury and in chronic lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), an abnormal feedback between fibroblasts and the altered ECM disrupts tissue homeostasis and leads to a vicious cycle of fibrotic changes resulting in tissue remodeling. In line with this, using 3D hydrogel culture models with embedded lung fibroblasts have enabled the assessment of the various mechanisms involved in driving defective (fibrotic) fibroblast function in the lung’s 3D ECM environment. In this review, we provide a summary of various studies that used these 3D hydrogel models to assess the regulation of the ECM on lung fibroblast phenotype and function in altered lung ECM homeostasis in health and in chronic respiratory disease.
Related Links	https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-023-02548-6.pdf
Ending Page	15
Page Count	15
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12931-023-02548-6
Journal	Respiratory Research
Issue Number	1
Volume Number	24
Language	English
Publisher	BioMed Central
Publisher Date	2023-10-05
Access Restriction	Open
Subject Keyword	Pneumology Respiratory System Lung fibroblasts 3D hydrogels Extracellular matrix (ECM) Fibrosis ECM stiffness Pneumology/Respiratory System
Content Type	Text
Resource Type	Review
Subject	Pulmonary and Respiratory Medicine
Journal Impact Factor	4.7/2023
5-Year Journal Impact Factor	5.3/2023

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