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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Ponnampalam, Jaya Seligmann, George Gandhi, Tanaya Parmar, Dilen |
| Abstract | We would like to comment on the article entitled “Association between cytokine profiles and lung injury in COVID-19 pneumonia” by Li-Da Chen and colleagues, with respect to emerging data regarding the immunopathogenesis of COVID-19. Chen et al. demonstrated the relevance of IL-2R, IL-6 and TNF-α in the cytokine storm and IL-6 as an independent predictor for COVID-19 severity. Del Valle et al. corroborated these findings with regard to IL-6 and disease severity, however, they also showed IL-8 to be of significance. This may be explained by the varying techniques used by the two studies to determine severity. Further studies including critically ill patients and the analysis of mortality rates in this patient cohort would greatly enhance the clinical relevance of these findings. As speculated by Chen et al., early studies on the use of tocilizumab in COVID-19 patients were promising, however, full results from ongoing trials are required to confirm a survival benefit in patients treated with tocilizumab. Moreover, investigating the roles of other pro-inflammatory cytokines and their impact on disease severity could potentially inform novel therapeutic targets. |
| Related Links | https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-020-01548-0.pdf |
| Ending Page | 3 |
| Page Count | 3 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12931-020-01548-0 |
| Journal | Respiratory Research |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-11-30 |
| Access Restriction | Open |
| Subject Keyword | Pneumology Respiratory System Coronavirus disease 2019 Cytokines Interleukin-6 Tocilizumab Pneumology/Respiratory System |
| Content Type | Text |
| Subject | Pulmonary and Respiratory Medicine |
| Journal Impact Factor | 4.7/2023 |
| 5-Year Journal Impact Factor | 5.3/2023 |
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