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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Valenzuela, Claudia Torrisi, Sebastiano Emanuele Kahn, Nicolas Quaresma, Manuel Stowasser, Susanne Kreuter, Michael |
| Abstract | The approvals of nintedanib and pirfenidone changed the treatment paradigm in idiopathic pulmonary fibrosis (IPF), and increased our understanding of the underlying disease mechanisms. Nonetheless, many challenges and unmet needs remain in the management of patients with IPF and other progressive fibrosing interstitial lung diseases.This review describes how the nintedanib clinical programme has helped to address some of these challenges. Data from this programme have informed changes to the IPF diagnostic guidelines, the timing of treatment initiation, and the assessment of disease progression. The use of nintedanib to treat patients with advanced lung function impairment, concomitant emphysema, patients awaiting lung transplantation and patients with IPF and lung cancer is discussed. The long-term use of nintedanib and an up-to-date summary of nintedanib in clinical practice are discussed. Directions for future research, namely emerging therapeutic options, precision medicine and other progressive fibrosing interstitial lung diseases, are described.Further developments in these areas should continue to improve patient outcomes. |
| Related Links | https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-019-1269-6.pdf |
| Ending Page | 15 |
| Page Count | 15 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12931-019-1269-6 |
| Journal | Respiratory Research |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-01-06 |
| Access Restriction | Open |
| Subject Keyword | Pneumology Respiratory System nintedanib idiopathic pulmonary fibrosis literature review challenges Pneumology/Respiratory System |
| Content Type | Text |
| Resource Type | Review |
| Subject | Pulmonary and Respiratory Medicine |
| Journal Impact Factor | 4.7/2023 |
| 5-Year Journal Impact Factor | 5.3/2023 |
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