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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Du, Houwei Pan, Xiaobin Liu, Nan Chen, Junnian Chen, Xiaoling Werring, David J. Ambler, Gareth Li, Xiaoqing Chen, Ronghua Zhang, Yixian Huang, Huayao Lin, Feifei Xia, Pincang Chen, Chao Zheng, Zhenyang Wu, Sangru Lei, Hanhan Gao, Lei Huang, Mingxu Lin, Kexu Xu, Xiaoping Luo, Yukun Zhao, Ziwen Li, Chen Lin, Hailong Lin, Yu Huang, Zhenghui Cao, Rongxiang Chen, Limin |
| Abstract | Background Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved. Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden. Methods We included 164 (61.8 ± 13.6 years) patients with COVID-19 in this retrospective study. We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness. We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model. Results Sixteen (9.8%) patients had no vascular risk factors; 38 (23.2%) had 1; 58 (35.4%) had 2; 34 (20.7%) had 3; and 18 (10.9%) had ≥4 risk factors. Twenty-nine patients (17.7%) experienced severe COVID-19 disease with a median (14 [7–27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4.47 per 1000-patient days (95%CI 3.10–6.43). Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P < 0.001) stratified by the number of vascular risk factors. After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden remained associated with an increasing risk of severe COVID-19 illness. Conclusions Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures. |
| Related Links | https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-020-01510-0.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12931-020-01510-0 |
| Journal | Respiratory Research |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-09-21 |
| Access Restriction | Open |
| Subject Keyword | Pneumology Respiratory System Vascular risk factor Coronavirus disease 2019 Prognosis Pneumology/Respiratory System |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
| Journal Impact Factor | 4.7/2023 |
| 5-Year Journal Impact Factor | 5.3/2023 |
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