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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Wang, Hao Lu, Hao Zhang, Xiao-Meng Goto, Ken-ichiro Kobayashi, Eiichi Yoshida, Yoichi Adachi, Akihiko Matsutani, Tomoo Iwadate, Yasuo Mine, Seiichiro Machida, Toshio Sata, Mizuki Yamagishi, Kazumasa Iso, Hiroyasu Sawada, Norie Tsugane, Shoichiro Kamitsukasa, Ikuo Wada, Takeshi Aotsuka, Akiyo Sugimoto, Kazuo Takizawa, Hirotaka Kashiwado, Koichi Shin, Hideo Tomiyoshi, Go Nakamura, Rika Shinmen, Natsuko Kuroda, Hideyuki Xu, Anding Hiwasa, Takaki |
| Abstract | Background Ischemic stroke, including transient ischemic attack (TIA) and acute-phase cerebral infarction (aCI), is a serious health problem in the aging society. Thus, this study aimed to identify TIA and aCI biomarkers. Methods In 19 patients with TIA, candidate antigens recognized by serum IgG autoantibodies were screened using a human aortic endothelial cell cDNA library. Through amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA), serum antibody levels against the candidate antigens were examined in healthy donor (HD), TIA, and aCI cohorts (n = 285, 92, and 529). The plasma antibody levels in the Japan Public Health Center-based Prospective Cohort Study (1991–1993) were also examined. Results The candidate antigens were aldolase A (ALDOA) and fumarate hydratase (FH). In AlphaLISA, patients with TIA or aCI had higher anti-ALDOA antibody (ALDOA-Ab) and anti-FH antibody (FH-Ab) levels than the HDs (P < 0.05). In a multivariate logistic regression analysis, the ALDOA-Ab (odds ratio [OR]: 2.46, P = 0.0050) and FH-Ab (OR: 2.49, P = 0.0037) levels were independent predictors of TIA. According to the case–control study, the ALDOA-Ab (OR: 2.50, P < 0.01) and FH-Ab (OR: 2.60, P < 0.01) levels were associated with aCI risk. In a correlation analysis, both ALDOA-Abs and FH-Abs were well associated with hypertension, coronary heart disease, and habitual smoking. These antibody levels also correlated well with maximum intima–media thickness, which reflects atherosclerotic stenosis. Conclusions ALDOA-Abs and FH-Abs can be novel potential biomarkers for predicting atherosclerotic TIA and aCI. |
| Related Links | https://bmcneurol.biomedcentral.com/counter/pdf/10.1186/s12883-021-02301-w.pdf |
| Ending Page | 13 |
| Page Count | 13 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14712377 |
| DOI | 10.1186/s12883-021-02301-w |
| Journal | BMC Neurology |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-07-09 |
| Access Restriction | Open |
| Subject Keyword | Neurology Neurochemistry Neurosurgery Transient ischemic attack Cerebral infarction ALDOA FH Antibody biomarker |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) |
| Journal Impact Factor | 2.2/2023 |
| 5-Year Journal Impact Factor | 2.5/2023 |
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