NDLI: The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy

Content Provider	Springer Nature : BioMed Central
Author	Noble, Jonathan J. Chruscikowski, Emily Fry, Nicola R. D. Lewis, Andrew P. Gough, Martin Shortland, Adam P.
Abstract	Background Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle volume and body mass in young people with bilateral cerebral palsy and their typically developing peers. Methods Twenty-five participants with bilateral cerebral palsy (aged 14.7±3.0 years, GMFCS level I-III) and 25 of their typically developing peers (aged 16.8±3.3 years) took part in this study. None of the participants had undergone orthopaedic surgery, botulinum toxin injections, or serial casting in the previous year. All participants underwent magnetic resonance imaging of both lower limbs. Nine major muscles of each lower limb were individually manually segmented and the muscle volumes calculated. Results Body mass and total lower limb muscle volume were significantly linearly related in both the cerebral palsy (R2 = 0.75, p<0.001) and typically developing (R2 = 0.77, p<0.001) groups. The slope of the relationship between muscle volume and body mass was significantly shallower in the cerebral palsy group compared to the typically developing group (p=0.007). Conclusions This cross-sectional study suggests that the increase in size of lower limb muscles relative to body mass is reduced in adolescents and young adults with cerebral palsy. Longitudinal studies are required to further investigate altered muscle growth trajectories in this group and their impact on long-term mobility.
Related Links	https://bmcneurol.biomedcentral.com/counter/pdf/10.1186/s12883-017-1005-0.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	14712377
DOI	10.1186/s12883-017-1005-0
Journal	BMC Neurology
Issue Number	1
Volume Number	17
Language	English
Publisher	BioMed Central
Publisher Date	2017-12-29
Access Restriction	Open
Subject Keyword	Neurology Neurochemistry Neurosurgery Cerebral palsy Muscle volume Magnetic resonance imaging Growth Musculoskeletal
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical)
Journal Impact Factor	2.2/2023
5-Year Journal Impact Factor	2.5/2023

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