NDLI: Circadian course of the P300 ERP in patients with amyotrophic lateral sclerosis - implications for brain-computer interfaces (BCI)

Content Provider	Springer Nature : BioMed Central
Author	Erlbeck, Helena Mochty, Ursula Kübler, Andrea Real, Ruben G. L.
Abstract	Background Accidents or neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) can lead to progressing, extensive, and complete paralysis leaving patients aware but unable to communicate (locked-in state). Brain-computer interfaces (BCI) based on electroencephalography represent an important approach to establish communication with these patients. The most common BCI for communication rely on the P300, a positive deflection arising in response to rare events. To foster broader application of BCIs for restoring lost function, also for end-users with impaired vision, we explored whether there were specific time windows during the day in which a P300 driven BCI should be preferably applied. Methods The present study investigated the influence of time of the day and modality (visual vs. auditory) on P300 amplitude and latency. A sample of 14 patients (end-users) with ALS and 14 healthy age matched volunteers participated in the study and P300 event-related potentials (ERP) were recorded at four different times (10, 12 am, 2, & 4 pm) during the day. Results Results indicated no differences in P300 amplitudes or latencies between groups (ALS patients v. healthy participants) or time of measurement. In the auditory condition, latencies were shorter and amplitudes smaller as compared to the visual condition. Conclusion Our findings suggest applicability of EEG/BCI sessions in patients with ALS throughout normal waking hours. Future studies using actual BCI systems are needed to generalize these findings with regard to BCI effectiveness/efficiency and other times of day.
Related Links	https://bmcneurol.biomedcentral.com/counter/pdf/10.1186/s12883-016-0782-1.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	14712377
DOI	10.1186/s12883-016-0782-1
Journal	BMC Neurology
Issue Number	1
Volume Number	17
Language	English
Publisher	BioMed Central
Publisher Date	2017-01-07
Access Restriction	Open
Subject Keyword	Neurology Neurochemistry Neurosurgery Amyotrophic Lateral Sclerosis ALS P300 Auditory Visual Brain computer interface BCI
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical)
Journal Impact Factor	2.2/2023
5-Year Journal Impact Factor	2.5/2023

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