NDLI: Relationship between serum uric acid level and mild cognitive impairment in Chinese community elderly

Content Provider	Springer Nature : BioMed Central
Author	Liu, Miao Wang, Jianhua Zeng, Jing He, Yao
Abstract	Background To evaluate the association between SUA levels within a normal to high range and the risk of mild cognitive impairment (MCI) among community elderly. Methods The present study was based on 2102 community elderly from a cross-sectional study conducted in a representative urban area of Beijing between 2009 and 2010. The mean age were 71.2 ± 6.6 years old, 59.7% were female. Mini-Mental State Examination (MMSE) was used to assess cognitive function by trained neurology doctors. Results The prevalence of hyperuricemia and MCI was 16.7% and 15.9% respectively. With the increase of SUA levels, the prevalence of MCI showed a strong decreasing linear trend. Multiple logistic regression analysis showed ORs for MCI were 1.01(95% CI: 0.69–1.48), 1.50(95% CI: 0.85–2.64), 1.65(95% CI: 1.12–2.43) and 1.53(95% CI: 1.00–2.33), 1.84(95% CI: 1.27–2.90), 1.92(95% CI: 1.02–3.35) for the second, third and highest quarters among men and women respectively (with the lowest quartile as the reference). Conclusions Higher SUA levels, when in the normal range, were positively associated with cognitive function among Chinese community elderly, but this association was not robust among participants with hyperuricemia.
Related Links	https://bmcneurol.biomedcentral.com/counter/pdf/10.1186/s12883-017-0929-8.pdf
Ending Page	6
Page Count	6
Starting Page	1
File Format	HTM / HTML
ISSN	14712377
DOI	10.1186/s12883-017-0929-8
Journal	BMC Neurology
Issue Number	1
Volume Number	17
Language	English
Publisher	BioMed Central
Publisher Date	2017-08-01
Access Restriction	Open
Subject Keyword	Neurology Neurochemistry Neurosurgery Chinese Elderly Epidemiology Mild cognitive impairment Uric acid
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical)
Journal Impact Factor	2.2/2023
5-Year Journal Impact Factor	2.5/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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