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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Shi, Chuan Li, Chao Ye, Wei Ye, Wen-ling Li, Ming-xi |
| Abstract | Background Hemolytic uremic syndrome (HUS), a common subtype of thrombotic microangiopathy (TMA), is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Shiga toxin-producing Escherichia coli infection is the most common cause of post-diarrheal HUS. Kidney and central nervous system are the primary target organs. Case presentation A 64-year-old male presented with HUS following bloody diarrhea. Nephrotic-range proteinuria and hypoalbuminemia were present at the acute stage and renal histology revealed common TMA features. Neurological involvement presented as confusion and impaired cognitive function. Cranial magnetic resonance imaging demonstrated bilateral T2 hyperintensities in the brainstem and insula. The patient received plasma exchange and supportive care. Both the renal and neurological impairments were completely recovered 3 months after the onset. Conclusion We report an adult patient presenting with nephrotic-range proteinuria and central nervous system involvement at the acute phase of post-diarrheal HUS. The reversibility of the organ damages might predict a favorable outcome. |
| Related Links | https://bmcnephrol.biomedcentral.com/counter/pdf/10.1186/s12882-020-01979-3.pdf |
| Ending Page | 5 |
| Page Count | 5 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14712369 |
| DOI | 10.1186/s12882-020-01979-3 |
| Journal | BMC Nephrology |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-07-31 |
| Access Restriction | Open |
| Subject Keyword | Nephrology Internal Medicine Hemolytic uremic syndrome Nephrotic syndrome Central nervous system |
| Content Type | Text |
| Resource Type | Case study |
| Subject | Nephrology |
| Journal Impact Factor | 2.2/2023 |
| 5-Year Journal Impact Factor | 2.6/2023 |
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