| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Wang, Zuowei Fang, Yiru Yu, Shunying Yuan, Chengmei Hong, Wu Yi, Zhenghui Jiang, Sanduo John, R Kelsoe Wang, Zucheng |
| Abstract | Background Several linkage studies across multiple population groups provide convergent support for susceptibility loci for schizophrenia – and, more recently, for affective disorder – on chromosome 6q. We explore whether schizophrenia and affective disorder have common susceptibility gene on 6q in Han Chinese population. Methods In the present study, we genotyped 45 family trios from Han Chinese population with mixed family history of schizophrenia and affective disorder. Twelve short tandem repeat (STRs) markers were selected, which covered 102.19 cM on chromosome 6q with average spacing 9.29 cM and heterozygosity 0.78. The transmission disequilibrium test (TDT) was performed to search for susceptibility loci to schizophrenia and affective disorder. Results The results showed STRs D6S257, D6S460, D6S1021, D6S292 and D6S1581 were associated with susceptibility to psychotic disorders. When families were grouped into schizophrenia and affective disorder group, D6S257, D6S460 and D6S1021, which map closely to the centromere of chromosome 6q, were associated with susceptibility to schizophrenia. Meanwhile, D6S1581, which maps closely to the telomere, was associated with susceptibility to affective disorder. But after correction of multiple test, all above association were changed into no significance (P > 0.05). Conclusion These results suggest that susceptibility of schizophrenia and affective disorder not associated with loci on chromosome 6q in Han Chinese population. |
| Related Links | https://behavioralandbrainfunctions.biomedcentral.com/counter/pdf/10.1186/1744-9081-3-46.pdf |
| Ending Page | 5 |
| Page Count | 5 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17449081 |
| DOI | 10.1186/1744-9081-3-46 |
| Journal | Behavioral and Brain Functions |
| Issue Number | 1 |
| Volume Number | 3 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2007-09-14 |
| Access Restriction | Open |
| Subject Keyword | Neurosciences Neurology Behavioral Therapy Psychiatry Schizophrenia Affective Disorder Short Tandem Repeat Susceptibility Locus Psychotic Disorder |
| Content Type | Text |
| Resource Type | Article |
| Subject | Behavioral Neuroscience Medicine Biological Psychiatry Cognitive Neuroscience |
| Journal Impact Factor | 4.7/2023 |
| 5-Year Journal Impact Factor | 4.1/2023 |
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