NDLI: A gene × gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males

Content Provider	Springer Nature : BioMed Central
Author	Beaver, Kevin M Wright, John Paul DeLisi, Matt Walsh, Anthony Vaughn, Michael G Boisvert, Danielle Vaske, Jamie
Abstract	Background Antisocial behaviors are complex polygenic phenotypes that are due to a multifactorial arrangement of genetic polymorphisms. Little empirical research, however, has been undertaken that examines gene × gene interactions in the etiology of conduct disorder and antisocial behavior. This study examined whether adolescent conduct disorder and adult antisocial behavior were related to the dopamine D2 receptor polymorphism (DRD2) and the dopamine D4 receptor polymorphism (DRD4). Methods A sample of 872 male participants from the National Longitudinal Study of Adolescent Health (Add Health) completed self-report questionnaires that tapped adolescent conduct disorder and adult antisocial behavior. DNA was genotyped for DRD2 and DRD4. Results Multivariate regression analysis revealed that neither DRD2 nor DRD4 had significant independent effects on conduct disorder or antisocial behavior. However, DRD2 interacted with DRD4 to predict variation in adolescent conduct disorder and in adult antisocial behavior. Conclusion The results suggest that a gene × gene interaction between DRD2 and DRD4 is associated with the development of conduct disorder and adult antisocial behavior in males.
Related Links	https://behavioralandbrainfunctions.biomedcentral.com/counter/pdf/10.1186/1744-9081-3-30.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	17449081
DOI	10.1186/1744-9081-3-30
Journal	Behavioral and Brain Functions
Issue Number	1
Volume Number	3
Language	English
Publisher	BioMed Central
Publisher Date	2007-06-22
Access Restriction	Open
Subject Keyword	Neurosciences Neurology Behavioral Therapy Psychiatry Attention Deficit Hyperactivity Disorder Antisocial Behavior Gene Interaction Conduct Disorder Oppositional Defiant Disorder
Content Type	Text
Resource Type	Article
Subject	Behavioral Neuroscience Medicine Biological Psychiatry Cognitive Neuroscience
Journal Impact Factor	4.7/2023
5-Year Journal Impact Factor	4.1/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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