NDLI: Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis B to interferon alfa

Content Provider	Springer Nature : BioMed Central
Author	Wang, Shaoyang Huang, Dedong Sun, Shunlai Ma, Weimin Zhen, Qin
Abstract	In order to examine whether variation in interleukin-10 promoter polymorphism would predict the likelihood of sustain response of chronic hepatitis B to treatment with interferon alfa (IFN-α), the inheritance of 3 biallelic polymorphisms in the IL-10 gene promoter in patients with 52 chronic hepatitis B were determined by polymerase chain reaction (PCR)-bared techniques, restriction enzyme digestion or direct sequencing. The relationship to the outcome of antiviral therapy for chronic HBV infection was studied in 24 patients who had a virologically sustained response(SR) and in 28 non-responder(NR) to interferon alfa-2b and several IL-10 variants were more frequent among SR compared with NR. Carriage of the -592A allele, -592A/A genotype and -1082/-1819/-592 ATA haplotype was associated with SR. Our findings indicate that heterogeneity in the promoter region of the IL-10 gene has a role in determining the initial response of chronic hepatitis B to IFN-α therapy.
Related Links	https://virologyj.biomedcentral.com/counter/pdf/10.1186/1743-422X-8-28.pdf
Ending Page	6
Page Count	6
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/1743-422X-8-28
Journal	Virology Journal
Issue Number	1
Volume Number	8
Language	English
Publisher	BioMed Central
Publisher Date	2011-01-20
Access Restriction	Open
Subject Keyword	Virology Sustained Response Biallelic Polymorphism Fuzhou General Hospital Relapse HBeAg
Content Type	Text
Resource Type	Article
Subject	Virology Infectious Diseases
Journal Impact Factor	4/2023
5-Year Journal Impact Factor	3.8/2023

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