NDLI: Numerical simulation on the effects of drug eluting stents at different Reynolds numbers on hemodynamic and drug concentration distribution

Content Provider	Springer Nature : BioMed Central
Author	Chen, Yu Xiong, Yan Jiang, Wentao Yan, Fei Guo, Meng Wang, Qingyuan Fan, Yubo
Abstract	Background The changes of hemodynamics and drug concentration distribution caused by the implantation of drug eluting stents (DESs) in curved vessels have significant effects on In-Stent Restenosis. Methods A 3D virtual stent with 90°curvature was modelled and the distribution of wall shear stress (WSS) and drug concentration in this model were numerically studied at Reynolds numbers of 200, 400, 600, 800. Results The results showed that (1) the intensity of secondary flow at the 45° cross-section was stronger than that at the 90° cross-section; (2) As the Reynolds number increases, the WSS decreases. When the Reynolds number reaches 600, the low-WSS region only accounts for 3% of the total area. (3) The effects of Reynolds number on drug concentration in the vascular wall decreases in proportionally and then the blood velocity increased 4 times, the drug concentration in the vascular wall decreased by about 30%. (4) The size of the high drug concentration region is inversely proportional to the Reynolds number. As the blood velocity increases, the drug concentration in the DES decreases, especially at the outer bend. Conclusions It is beneficial for the patient to decrease vigorous activities and keep calm at the beginning of the stent implantation, because a substantial amount of the drug is released in the first two months of stent implantation, thus a calm status is conducive to drug release and absorption; Subsequently, appropriate exercise which increases the blood velocity is helpful in decreasing regions of low-WSS.
Related Links	https://biomedical-engineering-online.biomedcentral.com/counter/pdf/10.1186/1475-925X-14-S1-S16.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/1475-925X-14-S1-S16
Journal	BioMedical Engineering OnLine
Issue Number	1
Volume Number	14
Language	English
Publisher	BioMed Central
Publisher Date	2015-01-09
Access Restriction	Open
Subject Keyword	Biomedical Engineering and Bioengineering Biomaterials Biotechnology Biomedical Engineering DES curved artery secondary flow Reynolds number WSS drug concentration Biomedical Engineering/Biotechnology
Content Type	Text
Resource Type	Article
Subject	Biomaterials Radiological and Ultrasound Technology Biomedical Engineering Radiology, Nuclear Medicine and Imaging
Journal Impact Factor	2.9/2023
5-Year Journal Impact Factor	3.5/2023

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