NDLI: The necessity of identifying the basal glucose set-point in the IVGTT for patients with Type 2 Diabetes

Content Provider	Springer Nature : BioMed Central
Author	Othman, Nor Azlan Docherty, Paul D Krebs, Jeremy D Bell, Damon A Chase, J Geoffrey
Abstract	Background The model-based dynamic insulin sensitivity and secretion test (DISST) uses fasting glucose (G 0 ) as the basal glucose (G B ) concentration when assessing insulin sensitivity (SI). However, this model was developed in a healthy, normoglycaemic cohort. We sought to determine the suitability the DISST model has for individuals with established type 2 diabetes (T2D). Methods 14 participants with established T2D were recruited to take part in a dietary intervention study. Insulin-modified intravenous glucose tolerance tests (IM-IVGTT) were undertaken at week 0, 12 and 24 and were used with DISST model to identify G B . A total of 36 tests were conducted across 12 participants throughout the study. Measured G 0 and identified G B values were compared using a Kolmogorov-Smirnov (KS) and signed rank (RS) test for the cohort. Results There were significant differences between the G 0 and identified G B values in this cohort (prs and pks < 0.0001), although both values were well correlated (R = 0.70). The residual plot demonstrates that the modified model captures the behaviour of the participants more accurately than the original model. Conclusions This analysis has shown that G B is an important variable for modelling the glycaemic behaviour in T2D. These findings suggest that the original DISST model, while appropriate for normoglycaemic cohorts, needs to model basal glucose level as a variable for assessing individuals with established T2D.
Related Links	https://biomedical-engineering-online.biomedcentral.com/counter/pdf/10.1186/s12938-015-0015-7.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12938-015-0015-7
Journal	BioMedical Engineering OnLine
Issue Number	1
Volume Number	14
Language	English
Publisher	BioMed Central
Publisher Date	2015-03-03
Access Restriction	Open
Subject Keyword	Biomedical Engineering and Bioengineering Biomaterials Biotechnology Biomedical Engineering Basal glucose concentration DISST Insulin resistance Insulin sensitivity Biomedical Engineering/Biotechnology
Content Type	Text
Resource Type	Article
Subject	Biomaterials Radiological and Ultrasound Technology Biomedical Engineering Radiology, Nuclear Medicine and Imaging
Journal Impact Factor	2.9/2023
5-Year Journal Impact Factor	3.5/2023

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